1-(二乙氧基甲基)咪唑合成路线 （共 10 条）
反应条件
n-butyllithium 1.) -40 deg C, 15 min; 2.) -40 deg C, 5 min, room temp., overnight; Yield given. Multistep reaction;
参考文献
Curtis, N.J.; Brown, R.S.
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 4038 - 4040
反应条件
1: 1-(1,1-diethoxymethyl)-1H-imidazole With lithium; isoprene in tetrahydrofuran T=0°C; 1.5 h; 2: benzaldehyde in tetrahydrofuran T=0°C; 0.75 h;
参考文献
Torregrosa, Rosario; Pastor, Isidro M.; Yus, Miguel
Tetrahedron, 2007 , vol. 63, # 4 p. 947 - 952
反应条件
water T=25°C; pH 1-11; Rate constantMechanismEquilibrium constant;
参考文献
Brown, R. S.; Ulan, J. G.
Journal of the American Chemical Society, 1983 , vol. 105, # 8 p. 2382 - 2388
反应条件
water T=25°C; pH 1-11; Rate constantMechanismEquilibrium constant;
参考文献
Brown, R. S.; Ulan, J. G.
Journal of the American Chemical Society, 1983 , vol. 105, # 8 p. 2382 - 2388
反应条件
1: 1-(1,1-diethoxymethyl)-1H-imidazole With n-butyllithium in tetrahydrofuran; hexane T=-55 - -35°C; 0.25 h; 2: N,N-dimethyl acetamide in tetrahydrofuran; hexane T=20°C; 25.5833 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1785418 A1, 2007 ;
Location in patent: Page/Page column 60-61 ;
反应条件
n-butyllithium 1.) THF, hexane, -40 deg C, 15 min; 2.) 15 min, -40 deg C, room temp., overnight; Yield given. Multistep reaction;
参考文献
Curtis, N.J.; Brown, R.S.
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 4038 - 4040
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-35°C; 2: With 1,2,2-trichloro-1,1,2-trichloro-ethane in tetrahydrofuran; hexane T=-35°C; 0.0833333 h; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
Otsuka Pharmaceutical Company, Limited
Patent: EP1553088 A1, 2005 ;
Location in patent: Page/Page column 52 ;
反应条件
toluene-4-sulfonic acid
T=130°C; 4 h;
参考文献
Torregrosa, Rosario; Pastor, Isidro M.; Yus, Miguel
Tetrahedron, 2007 , vol. 63, # 4 p. 947 - 952
反应条件
in tetrahydrofuran; hexane
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5208235 A1, 1993 ;
反应条件
camphor-10-sulfonic acid in N,N-dimethyl-formamide
T=70 - 80°C; different secondary amines; Product distribution;
参考文献
Bienayme
Tetrahedron Letters, 1998 , vol. 39, # 24 p. 4255 - 4258
