6-氯-吡嗪-4-羧酸乙酯合成路线 （共 6 条）
反应条件
1: With hydrazine in ethanol; water
0.333333 h; Heating / reflux;
2: With trichlorophosphate
T=90°C; 0.5 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/84917 A1, 2003 ;
Location in patent: Page/Page column 98 ;
参考文献
Obshchestvo S Ogranichennoy Otvetstvennostyou "Fusion Pharma"; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich
Patent: EP2743266 A2, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: sulfuric acid
2: thionyl chloride / ethanol
3: hydrazine hydrate / water; ethanol; tetrahydrofuran
4: ethyl acetate
View Scheme
参考文献
Obshchestvo S Ogranichennoy Otvetstvennostyou "Fusion Pharma"; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich
Patent: EP2743266 A2, 2014 ;
反应条件
1: thionyl chloride / ethanol
2: hydrazine hydrate / water; ethanol; tetrahydrofuran
3: ethyl acetate
View Scheme
参考文献
Obshchestvo S Ogranichennoy Otvetstvennostyou "Fusion Pharma"; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich
Patent: EP2743266 A2, 2014 ;
反应条件
1: hydrazine hydrate / water; ethanol; tetrahydrofuran
2: ethyl acetate
View Scheme
参考文献
Obshchestvo S Ogranichennoy Otvetstvennostyou "Fusion Pharma"; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich
Patent: EP2743266 A2, 2014 ;
反应条件
1: trichlorophosphate
2: sulfuric acid
3: thionyl chloride / ethanol
4: hydrazine hydrate / water; ethanol; tetrahydrofuran
5: ethyl acetate
View Scheme
参考文献
Obshchestvo S Ogranichennoy Otvetstvennostyou "Fusion Pharma"; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich
Patent: EP2743266 A2, 2014 ;
