1-[4-[[4-(2-氧代-3H-苯并咪唑-1-基)-1-哌啶基]甲基]苯基]-2-苯基-乙烷-1,2-二酮合成路线 （共 3 条）
反应条件
1: With PS-DIEA in dichloromethane
T=20°C;
2: With fluorous-tagged thiol
参考文献
Lindsley, Craig W.; Bogusky, Michael J.; Leister, William H.; McClain, Ray T.; Robinson, Ronald G.; Barnett, Stanley F.; Defeo-Jones, Deborah; Ross III, Charles W.; Hartman, George D.
Tetrahedron Letters, 2005 , vol. 46, # 16 p. 2779 - 2782
反应条件
acetic acid in ethanol
T=160°C; 0.166667 h; microwave irradiation;
参考文献
Zhao, Zhijian; Robinson, Ronald G.; Barnett, Stanley F.; Defeo-Jones, Deborah; Jones, Raymond E.; Hartman, George D.; Huber, Hans E.; Duggan, Mark E.; Lindsley, Craig W.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 49 - 53
反应条件
1: 1,2-diaminobenzene-4-carboxylic acid; 1-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylethane-1,2-dione With acetic acid in ethanol
T=160°C; 0.166667 h; microwave irradiation;
2: 1-amino-2-diethylamino-ethane With PS-DCC; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine in dichloromethane
Further stages.;
参考文献
Zhao, Zhijian; Robinson, Ronald G.; Barnett, Stanley F.; Defeo-Jones, Deborah; Jones, Raymond E.; Hartman, George D.; Huber, Hans E.; Duggan, Mark E.; Lindsley, Craig W.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 49 - 53
