1-环己基-4-甲氧基苯合成路线 （共 57 条）
反应条件
hydrogen bromide; acetic acid
参考文献
Bartlett; Garland
Journal of the American Chemical Society, 1927 , vol. 49, p. 2100
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Bodroux
Annales de Chimie (Cachan, France), 1929 , vol. <10> 11, p. 519,525
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1928 , vol. 186, p. 1005
反应条件
N,N,N',N,-tetramethylethylenediamine; iron(III) chloride in tetrahydrofuran
T=25°C; 0.5 h;
参考文献
Japan Science and Technology Agency
Patent: EP1724248 A1, 2006 ;
Location in patent: Page/Page column 20-22 ;
反应条件
1: (4-methoxyphenyl)-boronic acid With NiI2; sodium hexamethyldisilazane; trans-(+/-)-2-aminocyclohexan-1-ol hydrochloride; air in isopropyl alcohol
T=20°C; 0.0833333 h;
2: 1-trans-IODO-4-CYCLOHEXYL in isopropyl alcohol
T=60°C; Suzuki reaction; 6 h;
参考文献
Gonzalez-Bobes, Francisco; Fu, Gregory C.
Journal of the American Chemical Society, 2006 , vol. 128, # 16 p. 5360 - 5361
反应条件
Fe(acac)3; N,N,N',N,-tetramethylethylenediamine; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in tetrahydrofuran
T=0°C; 1.33333 h;
参考文献
Cahiez, Gerard; Habiak, Vanessa; Duplais, Christophe; Moyeux, Alban
Angewandte Chemie - International Edition, 2007 , vol. 46, # 23 p. 4364 - 4366
反应条件
1: 1-bromocyclohexane With [Fe(C2H4)4][Li(tmeda)]2 in tetrahydrofuran
T=-20°C;
2: 4-methoxyphenyl magnesium bromide in tetrahydrofuran; diethyl ether
T=-20°C; Further stages.;
参考文献
Fuerstner, Alois; Martin, Ruben; Krause, Helga; Seidel, Guenter; Goddard, Richard; Lehmann, Christian W.
Journal of the American Chemical Society, 2008 , vol. 130, # 27 p. 8773 - 8787
反应条件
anhydrous iron chloride; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran
T=0°C; 3 h; Inert atmosphere;
参考文献
SALTIGO GMBH
Patent: US2009/247764 A1, 2009 ;
Location in patent: Page/Page column 7 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C;
参考文献
Sanofi-Aventis
Patent: US2006/135575 A1, 2006 ;
Location in patent: Page/Page column 18 ;
反应条件
iron (III) acetylacetonate; ethylene dibromide in tetrahydrofuran
T=20°C; 3 h; Inert atmosphere;
参考文献
Cahiez, Gerard; Foulgoc, Laura; Moyeux, Alban
Angewandte Chemie, International Edition, 2009 , vol. 48, # 16 p. 2969 - 2972
反应条件
1: cyclohexyl magnesium bromide With zinc(II) chloride in tetrahydrofuran
T=20°C; 1 h;
2: para-iodoanisole With dichloro bis(acetonitrile) palladium(II) in tetrahydrofuran
T=20°C; Negishi coupling; 2 h; Further stages.;
参考文献
Luo, Xiancai; Zhang, Heng; Duan, Hui; Liu, Qiang; Zhu, Lizheng; Zhang, Tony; Lei, Aiwen
Organic Letters, 2007 , vol. 9, # 22 p. 4571 - 4574
反应条件
1: 1-bromocyclohexane With pyrene; zinc in N,N-dimethyl-formamide
T=20°C; 1 h;
2: para-iodoanisole With bis (triortho-tolylphosphine)palladium(II) chloride in tetrahydrofuran; N,N-dimethyl-formamide
T=70°C; 3 h;
参考文献
Kurono, Nobuhito; Inoue, Tomio; Tokuda, Masao
Tetrahedron, 2005 , vol. 61, # 47 p. 11125 - 11131
