(S)-(-)-1-苯基-1-丙醇合成路线 （共 162 条）
反应条件
dihydrogen peroxide 5 h; chloroperoxidase from Caldaromyces fumago, citrate buffer pH=5.0; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 117, # 42 p. 10419 - 10424
反应条件
Lipase PS in di-isopropyl ether T=30°C; Esterification; 25 h; Enzymatic reaction;
参考文献
Journal of Organic Chemistry, , vol. 65, # 1 p. 83 - 88
反应条件
lipase from Pseudomonas cepacia immobilized on ceramic in toluene T=40°C; 4 h;
参考文献
Monatshefte fur Chemie, , vol. 134, # 8 p. 1151 - 1157
反应条件
1: With (R)-2-tert-butyl-quinazolinap rhodium; benzo[1,3,2]dioxaborole in tetrahydrofuran T=20°C; 2 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; ethanol T=0 - 20°C; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 69, # 20 p. 6572 - 6589
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 12 h;
参考文献
Chemical Communications, , # 21 p. 2151 - 2153
反应条件
Birman's catalyst; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 12 h; optical yield given as percent eeenantioselective reaction;
参考文献
Heterocycles, , vol. 77, # 2 p. 801 - 810
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=20°C; Inert atmosphere; 2: With immobilized Candida antarctica Lipase B; water in hexane T=30°C; pH=6.5; 24 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron, , vol. 66, # 40 p. 8060 - 8067
反应条件
1: ethyl bromide With magnesium in diethyl ether Inert atmosphere; 2: benzaldehyde With titanium(IV) isopropylate; (Sa)-2'-[(R)-hydroxy(phenyl)methyl]-(1,1'-binaphthalen)-2-ol in toluene T=-40°C; Grignard reaction; 4.16 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 34 p. 6851 - 6855
反应条件
n-butyllithium; (2S,2'S)-2-hydroxymethyl-1-lt;(1-methylpyrrolidine-2-yl)methylgt;pyrrolidine in toluene T=-110°C; 1 h; investigation of the asymmetric addition of dialkylmagnesium to an aldehyde in toluene in presence (2S,2S')-2-hydroxymethyl-1-<(1-methylpyrrolidine-2-yl)methyl>pyrrolidine; Product distributionMechanism;
参考文献
Tetrahedron, , vol. 37, # 23 p. 4111 - 4119
反应条件
lipase Amano PS enzyme in di-isopropyl ether T=30°C; 25 h; Yield given. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 37, # 41 p. 7369 - 7372
