(S)-(-)-1-苯基-1-丙醇合成路线 （共 162 条）
反应条件
(R)-5-CF3-2-Ph-2,3-dihydroimidazo[1,2-a]pyridine; N-ethyl-N,N-diisopropylamine in chloroform 8 h; cooling; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 126, # 39 p. 12226 - 12227
反应条件
1: ethyl magnesium chloride With sodium methylate; zinc(II) chloride in diethyl ether T=0°C; Inert atmosphere; 2: benzaldehyde With (S)-N-(3-methyl-1-(1-pyrrolidin-1-yl)butan-2-yl)-P,P-di(naphthalen-1-yl)phosphinic amideamine T=20°C; 2 h; Neat (no solvent); optical yield given as percent eeenantioselective reaction;
参考文献
Synlett, , # 13 p. 2024 - 2028
反应条件
yeast strain Rhodotorula glutinis H93 T=28°C; 48 h; Microbiological reactionEnzymatic reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 102, p. 94 - 98
反应条件
hydrogenchloride Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Chemical Communications, , # 7 p. 847 - 848
反应条件
diethylzinc; [2-((S)-4-tBu-4,5-H2-oxazol-2-yl)-1-(C(OH)Ph2)]-ferrocene in n-heptane; toluene T=10°C; 12 h; Title compound not separated from byproducts.;
参考文献
Advanced Synthesis and Catalysis, , vol. 346, # 7 p. 867 - 872
反应条件
1: Ba(OH)2*H2O; Ph-pybox / [IrCl(cod)]2 / various solvent(s); H2O / 4 h / 20 °C 2: 82 percent / H2 / Pd(OH)2/C / methanol / 3 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 6 p. 2148 - 2153
反应条件
(R)-5-nitro-2-phenyl-2,3-dihydroimidazo[1,2-a]pyridine in chloroform-d1 T=20°C; 1 h; Resolution of racemate; Product distribution / selectivity;
参考文献
US2005/256150 A1, ;
Page/Page column 15 ;
反应条件
catalyst: (-)-3-exo-(dimethylamino)isoborneol in toluene toluene-soln. of catalyst added Bu2Zn at 30°C; after 15 min added Et2Zn; mixt. stirred for 10 min and cooled to 0°C; added benzaldehyde; mixt. stirred at 0°C for 6 h; quenched (water); analyzed by HPLC;
参考文献
Journal of the American Chemical Society, , vol. 111, # 11 p. 4028 - 4036
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 7 p. 1949 - 1953
反应条件
benzo[1,3,2]dioxaborole; chiral boron-bis(oxazoline) derivative in dichloromethane T=25°C; 48 h;
参考文献
European Journal of Organic Chemistry, , # 20 p. 4596 - 4608
