(S)-(-)-1-苯基-1-丙醇合成路线 （共 162 条）
反应条件
1: 99 percent / H2 / Rh-Al2O3 / tetrahydrofuran / 12 h / 760.05 Torr 2: 60 percent / Na(Hg) / methanol; H2O / 0.75 h 3: 75 percent / Et3N / CH2Cl2 / 0.17 h / -78 °C 4: 100 percent / H2; Et3N / Pd/C / ethyl acetate / 3 h / 760.05 Torr 5: Bu4NF / tetrahydrofuran / 12 h View Scheme
参考文献
Chemical Communications, , # 21 p. 2151 - 2153
反应条件
1: 60 percent / Na(Hg) / methanol; H2O / 0.75 h 2: 75 percent / Et3N / CH2Cl2 / 0.17 h / -78 °C 3: 100 percent / H2; Et3N / Pd/C / ethyl acetate / 3 h / 760.05 Torr 4: Bu4NF / tetrahydrofuran / 12 h View Scheme
参考文献
Chemical Communications, , # 21 p. 2151 - 2153
反应条件
1: 75 percent / Et3N / CH2Cl2 / 0.17 h / -78 °C 2: 100 percent / H2; Et3N / Pd/C / ethyl acetate / 3 h / 760.05 Torr 3: Bu4NF / tetrahydrofuran / 12 h View Scheme
参考文献
Chemical Communications, , # 21 p. 2151 - 2153
反应条件
1: 100 percent / H2; Et3N / Pd/C / ethyl acetate / 3 h / 760.05 Torr 2: Bu4NF / tetrahydrofuran / 12 h View Scheme
参考文献
Chemical Communications, , # 21 p. 2151 - 2153
反应条件
1: 95 percent / DIBAL-H / tetrahydrofuran; hexane / 2 h / 0 °C 2: (-)-diisopropyl tartrate; t-BuOOH; 4 Angstroem molecular sieves / Ti(OPr-i)4 / CH2Cl2; 2,2,4-trimethyl-pentane / 2 h / -25 °C 3: Et3N / CH2Cl2 / 1 h / 0 °C 4: 279.8 mg / NaI / 1,2-dimethoxy-ethane / 12 h / Heating 5: 100 percent / sym-collidine / CH2Cl2 / 0.25 h / -78 °C 6: 99 percent / H2 / Rh-Al2O3 / tetrahydrofuran / 12 h / 760.05 Torr 7: 60 percent / Na(Hg) / methanol; H2O / 0.75 h 8: 75 percent / Et3N / CH2Cl2 / 0.17 h / -78 °C 9: 100 percent / H2; Et3N / Pd/C / ethyl acetate / 3 h / 760.05 Torr 10: Bu4NF / tetrahydrofuran / 12 h View Scheme
参考文献
Chemical Communications, , # 21 p. 2151 - 2153
反应条件
1: (-)-diisopropyl tartrate; t-BuOOH; 4 Angstroem molecular sieves / Ti(OPr-i)4 / CH2Cl2; 2,2,4-trimethyl-pentane / 2 h / -25 °C 2: Et3N / CH2Cl2 / 1 h / 0 °C 3: 279.8 mg / NaI / 1,2-dimethoxy-ethane / 12 h / Heating 4: 100 percent / sym-collidine / CH2Cl2 / 0.25 h / -78 °C 5: 99 percent / H2 / Rh-Al2O3 / tetrahydrofuran / 12 h / 760.05 Torr 6: 60 percent / Na(Hg) / methanol; H2O / 0.75 h 7: 75 percent / Et3N / CH2Cl2 / 0.17 h / -78 °C 8: 100 percent / H2; Et3N / Pd/C / ethyl acetate / 3 h / 760.05 Torr 9: Bu4NF / tetrahydrofuran / 12 h View Scheme
参考文献
Chemical Communications, , # 21 p. 2151 - 2153
反应条件
1: Et3N / CH2Cl2 / 1 h / 0 °C 2: 279.8 mg / NaI / 1,2-dimethoxy-ethane / 12 h / Heating 3: 100 percent / sym-collidine / CH2Cl2 / 0.25 h / -78 °C 4: 99 percent / H2 / Rh-Al2O3 / tetrahydrofuran / 12 h / 760.05 Torr 5: 60 percent / Na(Hg) / methanol; H2O / 0.75 h 6: 75 percent / Et3N / CH2Cl2 / 0.17 h / -78 °C 7: 100 percent / H2; Et3N / Pd/C / ethyl acetate / 3 h / 760.05 Torr 8: Bu4NF / tetrahydrofuran / 12 h View Scheme
参考文献
Chemical Communications, , # 21 p. 2151 - 2153
反应条件
1: 97 percent / K2CO3 / tetrahydrofuran; H2O; methanol / 2.5 h 2: Et3N / CH2Cl2 / 1 h / 0 °C 3: 279.8 mg / NaI / 1,2-dimethoxy-ethane / 12 h / Heating 4: 100 percent / sym-collidine / CH2Cl2 / 0.25 h / -78 °C 5: 99 percent / H2 / Rh-Al2O3 / tetrahydrofuran / 12 h / 760.05 Torr 6: 60 percent / Na(Hg) / methanol; H2O / 0.75 h 7: 75 percent / Et3N / CH2Cl2 / 0.17 h / -78 °C 8: 100 percent / H2; Et3N / Pd/C / ethyl acetate / 3 h / 760.05 Torr 9: Bu4NF / tetrahydrofuran / 12 h View Scheme
参考文献
Chemical Communications, , # 21 p. 2151 - 2153
反应条件
1: 81 percent / Et3N; LiBr / tetrahydrofuran / 4 h / 20 °C 2: 95 percent / DIBAL-H / tetrahydrofuran; hexane / 2 h / 0 °C 3: (-)-diisopropyl tartrate; t-BuOOH; 4 Angstroem molecular sieves / Ti(OPr-i)4 / CH2Cl2; 2,2,4-trimethyl-pentane / 2 h / -25 °C 4: Et3N / CH2Cl2 / 1 h / 0 °C 5: 279.8 mg / NaI / 1,2-dimethoxy-ethane / 12 h / Heating 6: 100 percent / sym-collidine / CH2Cl2 / 0.25 h / -78 °C 7: 99 percent / H2 / Rh-Al2O3 / tetrahydrofuran / 12 h / 760.05 Torr 8: 60 percent / Na(Hg) / methanol; H2O / 0.75 h 9: 75 percent / Et3N / CH2Cl2 / 0.17 h / -78 °C 10: 100 percent / H2; Et3N / Pd/C / ethyl acetate / 3 h / 760.05 Torr 11: Bu4NF / tetrahydrofuran / 12 h View Scheme
参考文献
Chemical Communications, , # 21 p. 2151 - 2153
反应条件
toluene-4-sulfonic acid in dichloromethane; isopropyl alcohol T=23°C; 100 h;
参考文献
Helvetica Chimica Acta, , vol. 91, # 4 p. 581 - 597
