2-(4-吡啶基)-4-氨基嘧啶合成路线 （共 21 条）
反应条件
ammonium hydroxide; dimethyl sulfoxide in ethanol
参考文献
Sterling Drug Inc.
Patent: US4008235 A1, 1977 ;
反应条件
ammonium acetate in N-methyl-acetamide
参考文献
Sterling Drug Inc.
Patent: US4008235 A1, 1977 ;
反应条件
ammonia; sodium hydride
1.) DMF, 20 min, 2.) DMF, RT, overnight; Yield given. Multistep reaction;
参考文献
Lesher; Singh; Mielens
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 837 - 842
反应条件
sodium hydride
1.) DMF, 20 min, 2.) DMF, RT, overnight; Yield given. Multistep reaction;
参考文献
Lesher; Singh; Mielens
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 837 - 842
参考文献
Sterling Drug Inc.
Patent: US4008235 A1, 1977 ;
反应条件
pyridine
Ambient temperature;
参考文献
Lesher; Singh; Mielens
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 837 - 842
参考文献
Sterling Drug Inc.
Patent: US4008235 A1, 1977 ;
反应条件
pyridine
Ambient temperature;
参考文献
Lesher; Singh; Mielens
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 837 - 842
反应条件
pyridine
Ambient temperature;
参考文献
Lesher; Singh; Mielens
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 837 - 842
反应条件
1: 1.) NaNO2, aq. HCl, 2.) PhPOCl2 / 1.) H2O, RT, overnight, 2.) from 155 to 170 deg C, 5 h
2: 65 percent / H2O; ethanol / 5 h / Heating
View Scheme
参考文献
Lesher; Singh; Mielens
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 837 - 842
