(R)-1-苯基-2-丙炔-1-醇合成路线 （共 19 条）
反应条件
1: NCS; Ph3P / CH2Cl2 / 0 - 20 °C 2: n-BuLi; HMPA / tetrahydrofuran / -42 - 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 45 p. 8043 - 8045
反应条件
1: AD-mix-α; MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 20 °C 2: p-TsOH / CH2Cl2 / 20 °C 3: DIBAL-H / tetrahydrofuran / 0 - 20 °C 4: NCS; Ph3P / CH2Cl2 / 0 - 20 °C 5: n-BuLi; HMPA / tetrahydrofuran / -42 - 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 45 p. 8043 - 8045
反应条件
1: DIBAL-H / tetrahydrofuran / 0 - 20 °C 2: NCS; Ph3P / CH2Cl2 / 0 - 20 °C 3: n-BuLi; HMPA / tetrahydrofuran / -42 - 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 45 p. 8043 - 8045
反应条件
1: -78 - 0 °C 2: Et3N / CH2Cl2 3: 30.1 percent / 0.1M phosphate buffer / 4.8 h / Ambient temperature; SAM II lipase View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 5 p. 1485 - 1488
反应条件
(S)-N-(1-(tert-butylcarbamoyl)-1-(4-(dimethylamino)pyridin-3-yl)methyl)-L-valinemethyl ester; triethylamine in toluene T=-78°C; 15 h; enantioselective reaction;
参考文献
Heterocycles, , vol. 87, # 2 p. 329 - 340
反应条件
methanol; potassium carbonate T=20°C; 12 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 76, # 2 p. 500 - 511
反应条件
tetraproline chiral stationary phase packed on HPLC column in hexane; isopropyl alcohol Resolution of racemate;
参考文献
Chirality, , vol. 24, # 4 p. 329 - 338
反应条件
novozyme 435 in benzene T=32°C; 0.333333 h; Product distribution; Further Variations:Solventstime;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 19 p. 3117 - 31722
反应条件
With phosphate buffer 4.8 h; Ambient temperatureSAM II lipase;
参考文献
Waldinger, Claudia; Schneider, Manfred; Botta, Maurizio; Corelli, Federico; Summa, Vincenzo Tetrahedron Asymmetry, 1996 , vol. 7, # 5 p. 1485 - 1488
