5-甲基噻唑-4-甲酸乙酯合成路线 （共 5 条）
反应条件
isopentylnitrile in tetrahydrofuran Reflux;
参考文献
Gavardinas, Konstantinos; Green, Jonathan Edward; Jadhav, Prabhakar Kondaji; Matthews, Donald Paul
Patent: US2010/69404 A1, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
sodium cyanide in ethanol
参考文献
Synthesis, , p. 681 - 682
反应条件
diisobutylaluminium hydride; acetic acid in dichloromethane (CH2Cl2); dichloromethane; water
参考文献
Warner-Lambert Company
Patent: US6528510 B1, 2003 ;
反应条件
diisobutylaluminium hydride in dichloromethane 1.5 h;
参考文献
Hagen; Domagala; Gajda; Lovdahl; Tait; Wise; Holler; Hupe; Nouhan; Urumov; Zeikus; Lunney; Pavlovsky; Gracheck; Saunders; VanderRoest; Brodfuehrer
Journal of Medicinal Chemistry, 2001 , vol. 44, # 14 p. 2319 - 2332
反应条件
methanol; lithium borohydride in tetrahydrofuran
T=20°C; 16 h; Inert atmosphereCooling with ice;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
Location in patent: Paragraph 00348 ;
