12-氧代-5,8-二氧杂-2,11-二氮杂十五烷二酸 1-(9H-芴-9-基甲基)酯合成路线 （共 3 条）
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile
T=20°C; pH=8 - 9;
参考文献
Song, Aimin; Wang, Xiaobing; Zhang, Jinhua; Marik, Jan; Lebrilla, Carlito B.; Lam, Kit S.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 161 - 165
反应条件
1: acetonitrile / 3 h
2: 72 percent / diisopropylethylamine / acetonitrile / 20 °C / pH 8 - 9
View Scheme
参考文献
Song, Aimin; Wang, Xiaobing; Zhang, Jinhua; Marik, Jan; Lebrilla, Carlito B.; Lam, Kit S.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 161 - 165
反应条件
1: succinic acid anhydride; 2-[2-(2-aminoethoxy)ethoxy]-ethylamine in acetonitrile
3 h;
2: (9H-Fluoren-9-yl)-methyl chloroformate in water; acetonitrile
T=20°C; pH=7 - 8;
参考文献
Soriano, Aroa; Ventura, Ruben; Molero, Anabel; Hoen, Rob; Casado, Vicent; Corte, Antoni; Fanelli, Francesca; Albericio, Fernando; Lluis, Carmen; Franco, Rafael; Royo, Miriam
Journal of Medicinal Chemistry, 2009 , vol. 52, # 18 p. 5590 - 5602
