1-(3-氰基吡啶-2)-2-苯基-4-甲基哌嗪合成路线 （共 11 条）
反应条件
potassium hydroxide in water; dimethyl sulfoxide; toluene
参考文献
Singer, Claude; Liberman, Anita; Finkelstein, Nina
Patent: US2001/51718 A1, 2001 ;
反应条件
sulfuric acid; water; hydrogen; 5percent palladium-carbon catalyst deactivated with iron sulfate T=25 - 70°C; P=2205.22 Torr; 5 - 20 h; Product distribution / selectivity;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP1953150 A1, 2008 ;
Location in patent: Page/Page column 3-4 ;
反应条件
1: 63 percent / sodium hydroxide / ethane-1,2-diol / 7 h / 130 °C 2: 97 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 2 h / 55 - 60 °C 3: 91 percent / conc. sulfuric acid / CH2Cl2 / 3 h / Heating View Scheme
参考文献
WATSON PHARMA PRIVATE LIMITED
Patent: US2011/201804 A1, 2011 ;
反应条件
potassium fluoride in N,N-dimethyl-formamide
T=140°C; 6 h;
参考文献
Srinivasa Rao; Dandala; Handa; Sivakumaran; Raghava Reddyt; Naidu
Organic Preparations and Procedures International, 2007 , vol. 39, # 4 p. 399 - 402
反应条件
potassium fluoride in water; N,N-dimethyl-formamide
参考文献
Akzona Incorporated
Patent: US4062848 A1, 1977 ;
反应条件
potassium fluoride; N,N-dimethyl-formamide
参考文献
Sebastian, Sonny; Patel, Hetal Virendra; Thennati, Rajamannar
Patent: US2002/95038 A1, 2002 ;
反应条件
1-methyl-pyrrolidin-2-one
T=190°C; 0.333333 h;
参考文献
Lamazzi, Christelle; Dreau, Armelle; Bufferne, Christel; Flouzat, Christine; Carlier, Patrick; ter Halle, Rob; Besson, Thierry
Tetrahedron Letters, 2009 , vol. 50, # 31 p. 4502 - 4505
反应条件
1-methyl-pyrrolidin-2-one; potassium fluoride
T=180°C; 2 h; Autoclave;
参考文献
Lamazzi, Christelle; Dreau, Armelle; Bufferne, Christel; Flouzat, Christine; Carlier, Patrick; ter Halle, Rob; Besson, Thierry
Tetrahedron Letters, 2009 , vol. 50, # 31 p. 4502 - 4505
反应条件
1-methyl-pyrrolidin-2-one; potassium fluoride
T=190°C; 0.25 h; Microwave irradiation;
参考文献
Lamazzi, Christelle; Dreau, Armelle; Bufferne, Christel; Flouzat, Christine; Carlier, Patrick; ter Halle, Rob; Besson, Thierry
Tetrahedron Letters, 2009 , vol. 50, # 31 p. 4502 - 4505
反应条件
1-methyl-pyrrolidin-2-one; potassium fluoride
T=200°C; 0.25 h; Microwave irradiation;
参考文献
Lamazzi, Christelle; Dreau, Armelle; Bufferne, Christel; Flouzat, Christine; Carlier, Patrick; ter Halle, Rob; Besson, Thierry
Tetrahedron Letters, 2009 , vol. 50, # 31 p. 4502 - 4505
