5-溴-1,2,3,4-四氢萘合成路线 （共 18 条）
反应条件
1: With tetrafluoroboric acid; sodium nitrite in water 0.166667 h; Cooling with ice; 2: With copper(ll) bromide in dimethyl sulfoxide 0.5 h;
参考文献
SANOFI-AVENTIS; GEORGE, Pascal; HALL, Daniel; HARTUNG, Ryan; KOSLEY, JR., Raymond W.; SCOTESE, Anthony C.
Patent: WO2011/34828 A1, 2011 ;
Location in patent: Page/Page column 43 ;
WO 2011/034828 A1
反应条件
aluminum oxide; bromine 0.0166667 h; Ambient temperature;
参考文献
Ranu; Sarkar; Chakraborty
Synthetic Communications, 1992 , vol. 22, # 8 p. 1095 - 1099
反应条件
hydrogen bromide in water T=100°C; 8 h;
参考文献
Lo, Ching-Yu; Kumar, Manyam Praveen; Chang, Hsu-Kai; Lush, Shie-Fu; Liu, Rai-Shung
Journal of Organic Chemistry, 2005 , vol. 70, # 25 p. 10482 - 10487
反应条件
hydrogenchloride; tert.-butylnitrite in acetonitrile
反应条件
bromine; iron in tetrachloromethane 20 h; Ambient temperature; Product distribution;
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 3-4 p. 96 - 104
反应条件
1: 71 percent / H2 / Raney-nickel / ethanol / 24 h / 150 °C / 114000 Torr 2: 1) 30percent aq. HBr, NaNO2, 2) 48percent aq. HBr, CuBr / 1) water, 3 deg C, 2) a) 1 h, 0 deg C b) 3 h, reflux View Scheme
参考文献
Chemische Berichte, , vol. 124, # 9 p. 1989 - 1996
反应条件
sodium carbonate; lithium bromide in 1,4-dioxane T=50°C; 72 h;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 21 p. 1487 - 1489
反应条件
dimethylsulfoxide-d6; lithium bromide; 2,2,2-trimethylacetic acid T=37°C; Kinetics; Further Variations:Reagentsconcentrations;
参考文献
Journal of the American Chemical Society, , vol. 129, # 15 p. 4795 - 4799
反应条件
1: Br2 2: Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 35 p. 6709 - 6713
反应条件
1: With n-butyllithium in Dry THF; hexane T=-78 - 25°C; 1.16667 h; 2: With hydrogenchloride pH=1;
参考文献
ASTRAZENECA AB
Patent: WO2004/792 A1, 2003 ;
Location in patent: Page 22 ;
