4-(4-甲基苯氧基)苯甲醛合成路线 （共 12 条）
反应条件
sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; water in tetrahydrofuran; tert-butyl alcohol Pinnick oxidation;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1788 - 1792
反应条件
3-chloro-benzenecarboperoxoic acid Baeyer-Villiger oxidation;
参考文献
Merck and Co., Inc.
Patent: US6008237 A1, 1999 ;
反应条件
copper (II) acetate monohydrate; caesium carbonate in N,N-dimethyl-formamide
T=100°C; 4 h; Inert atmosphereSchlenk technique;
参考文献
Chen, Jiuxi; Wang, Xingyong; Zheng, Xingwang; Ding, Jinchang; Liu, Miaochang; Wu, Huayue
Tetrahedron, 2012 , vol. 68, # 43 p. 8905 - 8907
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=140°C; Ullmann Condensation; 24 h; Inert atmosphereGreen chemistry;
参考文献
Zhang, Ying-Peng; Jiao, Ya-Cong; Yang, Yun-Shang; Li, Chun-Lei
Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6494 - 6497
反应条件
Wilkinson's catalyst; water; caesium carbonate in N,N-dimethyl-formamide
T=100°C; 24 h;
参考文献
Zheng, Xingwang; Ding, Jinchang; Chen, Jiuxi; Gao, Wenxiao; Liu, Miaochang; Wu, Huayue
Organic Letters, 2011 , vol. 13, # 7 p. 1726 - 1729
反应条件
potassium carbonate in N,N-dimethyl acetamide
T=155°C;
参考文献
Dimmock, Jonathan R.; Puthucode, Ramanan N.; Smith, Jennifer M.; Hetherington, Mark; Quail, J. Wilson; Pugazhenthi, Uma; Lechler, Terry; Stables, James P.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 20 p. 3984 - 3997
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=100°C;
参考文献
Cui, Sun-Liang; Jiang, Zhi-Yong; Wang, Yan-Guang
Synlett, 2004 , # 10 p. 1829 - 1831
反应条件
sodium hydride; copper(I) bromide in pyridine
T=125°C; 18 h;
参考文献
Boger, Dale L.; Yohannes, Daniel
Tetrahedron Letters, 1989 , vol. 30, # 16 p. 2053 - 2056
反应条件
1.1: potassium hydroxide; dihydrogen peroxide / methanol; ethanol / |Reflux
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
2.2: 24 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Carrasco, Marta P.; Newton, Ana S.; Goncalves, Lidia; Gois, Ana; Machado, Marta; Gut, Jiri; Nogueira, Fatima; Haenscheid, Thomas; Guedes, Rita C.; Dos Santos, Daniel J.V.A.; Rosenthal, Philip J.; Moreira, Rui
European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 523 - 534
反应条件
1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 24 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Carrasco, Marta P.; Newton, Ana S.; Goncalves, Lidia; Gois, Ana; Machado, Marta; Gut, Jiri; Nogueira, Fatima; Haenscheid, Thomas; Guedes, Rita C.; Dos Santos, Daniel J.V.A.; Rosenthal, Philip J.; Moreira, Rui
European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 523 - 534
