4-(4-甲基苯氧基)苯甲醛合成路线 （共 12 条）
反应条件
1.1: sodium carbonate / N,N-dimethyl-formamide / 24 h / |Reflux
2.1: potassium hydroxide; dihydrogen peroxide / methanol; ethanol / |Reflux
3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
3.2: 24 h / 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Carrasco, Marta P.; Newton, Ana S.; Goncalves, Lidia; Gois, Ana; Machado, Marta; Gut, Jiri; Nogueira, Fatima; Haenscheid, Thomas; Guedes, Rita C.; Dos Santos, Daniel J.V.A.; Rosenthal, Philip J.; Moreira, Rui
European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 523 - 534
反应条件
1.1: sodium carbonate / N,N-dimethyl-formamide / 24 h / |Reflux
2.1: potassium hydroxide; dihydrogen peroxide / methanol; ethanol / |Reflux
3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C
3.2: 24 h / 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Carrasco, Marta P.; Newton, Ana S.; Goncalves, Lidia; Gois, Ana; Machado, Marta; Gut, Jiri; Nogueira, Fatima; Haenscheid, Thomas; Guedes, Rita C.; Dos Santos, Daniel J.V.A.; Rosenthal, Philip J.; Moreira, Rui
European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 523 - 534
