5-硝基-2-(2-吡啶)苯并噻唑合成路线 (共 2 条)
反应条件
1: With PPA
T=120 - 130°C; 6 h;
2: With sodium hydroxide in water
pH=10;
参考文献
ROTTAPHARM S.P.A.
Patent: EP1571142 A1, 2005 ;
Location in patent: Page/Page column 25 ;
反应条件
nitric acid in sulfuric acid
2 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974