4-溴-苯胺-2,3,5,6-D4合成路线 （共 2 条）
反应条件
1: With 4,4-dibromo-5-methyl-2,4-dihydro-3H-pyrazol-3-one in acetic acid
T=20°C; 15.5 h;
2: With potassium carbonate in water; acetic acid
pH=> 7;
参考文献
CONCERT PHARMACEUTICALS INC.; TUNG, Roger; MASSE, Craig, E.
Patent: WO2011/103457 A1, 2011 ;
Location in patent: Page/Page column 31; 32 ;
反应条件
sodium borodeuteride; palladium 10 on activated carbon; water-d2
T=150°C; sealed tubeMicrowave irradiationInert atmosphere;
参考文献
Derdau, Volker; Atzrodt, Jens; Zimmermann, Jochen; Kroll, Carsten; Brueckner, Francois
Chemistry - A European Journal, 2009 , vol. 15, # 40 p. 10397 - 10404
