1-苄基-4-(甲氧基甲基)-N-苯基哌啶-4-胺合成路线 （共 4 条）
反应条件
1: 4-(N-phenylamino)-1-phenylmethyl-4-piperidinylmethanol With sodium hydride in tetrahydrofuran
T=20 - 50°C;
2: methyl iodide in tetrahydrofuran
T=0 - 20°C;
参考文献
Srimurugan, Sankareswaran; Murugan, Kaliyappan; Chen, Chinpiao
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 12 p. 1421 - 1424
反应条件
sodium hydroxide; dimethyl sulfate in methanol; water; benzene
参考文献
Janssen Pharmaceutica N.V.
Patent: US3998834 A1, 1976 ;
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 6.25 h;
参考文献
Srimurugan, Sankareswaran; Murugan, Kaliyappan; Chen, Chinpiao
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 12 p. 1421 - 1424
反应条件
in diethyl ether; acetone; acetonitrile
参考文献
Janssen Pharmaceutica N.V.
Patent: US3998834 A1, 1976 ;
Title/Abstract Full Text Show Details
Janssen Pharmaceutica N.V.
Patent: US4179569 A1, 1979 ;
