[(R)-2-(2,4-二氯-苯基)-2-咪唑-1-甲基-[1,3]二氧杂烷-4-基]-甲醇合成路线 （共 8 条）
反应条件
sodium hydroxide in 1,4-dioxane 0.5 h; Heating;
参考文献
Baji; Kimny, Tan; Gasquez; Flammang; Compagnon; Delcourt; Mathieu; Viossat; Morgant; Nguyen-Huy
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 7-8 p. 637 - 650
反应条件
sodium hydroxide in 1,4-dioxane 1.5 h; Heating;
参考文献
Chapman, David R.; Bauer, Ludwig
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2053 - 2061
反应条件
1: 50 percent / pyridine / 3 h / 5 °C 2: 55 percent / dimethylformamide / 96 h / Heating 3: 96 percent / 5 N NaOH / dioxane / 0.5 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 32, # 7-8 p. 637 - 650
反应条件
1: 87 percent / Br2 / toluene / 1 h / Ambient temperature 2: 50 percent / pyridine / 3 h / 5 °C 3: 55 percent / dimethylformamide / 96 h / Heating 4: 96 percent / 5 N NaOH / dioxane / 0.5 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 32, # 7-8 p. 637 - 650
反应条件
1: 55 percent / dimethylformamide / 96 h / Heating 2: 96 percent / 5 N NaOH / dioxane / 0.5 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 32, # 7-8 p. 637 - 650
反应条件
1: p-TsOH*H2O / toluene; butan-1-ol / 24 h / Heating 2: 87 percent / Br2 / toluene / 1 h / Ambient temperature 3: 50 percent / pyridine / 3 h / 5 °C 4: 55 percent / dimethylformamide / 96 h / Heating 5: 96 percent / 5 N NaOH / dioxane / 0.5 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 32, # 7-8 p. 637 - 650
参考文献
De; Plattner; Bush; Jae; Diaz; Johnson; Perun
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2036 - 2038
参考文献
Chapman, David R.; Bauer, Ludwig
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2053 - 2061
