烟酸乙酯合成路线

参考文献

Balsamo, A.; Giorgi, I.; Lapucci, A.; Lucacchini, A.; Macchia, B.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 222 - 225

614-18-6烟酸乙酯+

75-05-8乙腈

30510-18-03-氧代-3-(3-吡啶基)丙腈

参考文献

El-Borai; Rizk; Abd-Aal; El-Deeb
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 92 - 96

614-18-6烟酸乙酯

75358-90-62-氰基烟酸乙酯

参考文献

GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102142 A1, 2013 ;

614-18-6烟酸乙酯

76196-79-7乙基6-氰基烟酸酯+

75358-90-62-氰基烟酸乙酯

参考文献

GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102145 A1, 2013 ;

614-18-6烟酸乙酯+

107-15-3乙二胺

6302-53-03-(4,5-二氢-1H-咪唑-2-基)吡啶

参考文献

Neef, Guenter; Eder, Ulrich; Sauer, Gerhard
Journal of Organic Chemistry, 1981 , vol. 46, # 13 p. 2824 - 2826

614-18-6烟酸乙酯+

124-40-3二甲胺

59-26-7N,N-二乙基烟酰胺

参考文献

REACTIMEX, S.A. DE C.V.
Patent: US2005/27120 A1, 2005 ;
Location in patent: Page/Page column 11 ;

614-18-6烟酸乙酯+

2283-11-6六乙基亚磷酰三胺

59-26-7N,N-二乙基烟酰胺

参考文献

Yakovleva, N. L.; Ivanova, S. N.; Balyakina, M. V.; Gunar, V. I.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 1 p. 54 - 57
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 1 p. 67 - 69

614-18-6烟酸乙酯

498-95-33-哌啶甲酸

参考文献

Akkerman et al.
Recueil des Travaux Chimiques des Pays-Bas, 1951 , vol. 70, p. 899,913

614-18-6烟酸乙酯+

151-50-8氰化钾

76196-79-7乙基6-氰基烟酸酯

参考文献

Synthesis, , # 6 art. no. M08404SS, p. 993 - 997

614-18-6烟酸乙酯

76196-79-7乙基6-氰基烟酸酯

参考文献