(2S,4s)-4-甲基谷氨酸合成路线 （共 21 条）
反应条件
1.1: DMAP / triethylamine; CH2Cl2 2.1: LiN(SiMe3)2 / tetrahydrofuran / -78 °C 2.2: tetrahydrofuran / -78 °C 3.1: LiOH / H2O; tetrahydrofuran 4.1: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1.1: DMAP / triethylamine; CH2Cl2 2.1: LiN(SiMe3)2 / tetrahydrofuran / 0.75 h / -78 °C 2.2: 28 percent / tetrahydrofuran / -78 °C 3.1: LiOH / H2O; tetrahydrofuran 4.1: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1: LiOH / H2O; tetrahydrofuran 2: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C 2: 6N aq. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 14 p. 2518 - 2520
反应条件
hydrogenchloride Heating; Title compound not separated from byproducts;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 14 p. 2518 - 2520
反应条件
hydrogenchloride; lithium hydroxide 1.) i-PrOH, overnight, 2.) AcOH, 30 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Synthesis, , # 8 p. 863 - 865
参考文献
Tetrahedron Asymmetry, , vol. 5, # 4 p. 731 - 744
反应条件
hydrogenchloride; sodium methylate 1.) MeOH, 25 deg C, 2.) EtOH, 80 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1865 - 1872
反应条件
Multistep reaction. Title compound not separated from byproducts.;
参考文献
Chemistry--A European Journal, , vol. 8, # 20 p. 4633 - 4648
反应条件
magnesium sulfate T=37°C; 2.5 h; Tris buffer (pH 8.9), leucine aminopeptidase; Further byproducts given;
参考文献
Bory, Sonia; Dubois, Joelle; Gaudry, Michel; Marquet, Andree; Lacombe, Liliane; Weinstein, Shulamith
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 3 p. 475 - 480
