1-苄氧基-4-(2-甲烷磺酰氧基乙基)苯合成路线 （共 14 条）
反应条件
1: 46.7 percent / Na2CO3 / dimethylformamide / 20 h / 70 °C 2: 88.5 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Janssens, Frans; Torremans, Joseph; Janssen, Marcel; Stokbroekx, Raymond A.; Luyckx, Marcel; Janssen, Paul A. J.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1934 - 1943
反应条件
triethylamine in dichloromethane
T=20°C; 8 h;
参考文献
Lebegue, Nicolas; Gallet, Sebastien; Flouquet, Nathalie; Carato, Pascal; Pfeiffer, Bruno; Renard, Pierre; Leonce, Stephane; Pierre, Alain; Chavatte, Philippe; Berthelot, Pascal
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7363 - 7373
反应条件
1: 85 percent / K2CO3 / acetone / 12 h / Heating
2: 54 percent / Et3N / CH2Cl2 / 8 h / 20 °C
View Scheme
参考文献
Lebegue, Nicolas; Gallet, Sebastien; Flouquet, Nathalie; Carato, Pascal; Pfeiffer, Bruno; Renard, Pierre; Leonce, Stephane; Pierre, Alain; Chavatte, Philippe; Berthelot, Pascal
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7363 - 7373
反应条件
1: 85 percent / K2CO3 / acetone / 12 h / Heating
2: 54 percent / Et3N / CH2Cl2 / 8 h / 20 °C
View Scheme
参考文献
Lebegue, Nicolas; Gallet, Sebastien; Flouquet, Nathalie; Carato, Pascal; Pfeiffer, Bruno; Renard, Pierre; Leonce, Stephane; Pierre, Alain; Chavatte, Philippe; Berthelot, Pascal
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7363 - 7373
参考文献
Warner-Lambert Company; Cocensys, Incorporated
Patent: US6124323 A1, 2000 ;
US 6124323 A
反应条件
sodium hydride
1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 75 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
in N-methyl-acetamide; carbon palladium; ethanol; mineral oil
参考文献
Hoffmann-La Roche Inc.
Patent: US4387100 A1, 1983 ;
US 4387100 A
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 68 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 85 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
