3-[4-(苄氧基)苯基]-1-丙醇合成路线 （共 33 条）
反应条件
1.1: 99 percent / H2 / Pd/C / ethyl acetate / 20 °C 2.1: NaH / dimethylformamide / 0.17 h / 0 °C 2.2: 72 percent / dimethylformamide / 20 °C 3.1: methanol / 16 h / 25 °C 4.1: 1.0 g / DIBAL-H / toluene / 0.75 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 14 p. 3359 - 3368
反应条件
1: 78 percent / KOH / ethanol / 5 h / Heating 2: 56 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 1 h / Heating View Scheme
参考文献
Bulletin of the Polish Academy of Sciences, Chemistry, , vol. 34, # 3-4 p. 115 - 122
反应条件
1: 89.1 percent / K2CO3; NaI / acetone / 48 h / Heating 2: 66.2 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 11 p. 919 - 937
反应条件
1: 89.1 percent / K2CO3; NaI / acetone / 48 h / Heating 2: 66.2 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 11 p. 919 - 937
反应条件
2: sodium tetrahydroborate; NiII chloride hexahydrate 3: lithium aluminium tetrahydride View Scheme
参考文献
Helvetica Chimica Acta, , vol. 95, # 9 p. 1666 - 1671
反应条件
magnesium in tetrahydrofuran 18 h; Ambient temperature;
参考文献
Henley-Smith, Peter; Whiting, Donald A.; Wood, Andrew F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 614 - 622
反应条件
1: 2.840 g / thionyl chloride / benzene; pyridine / 1 h / Ambient temperature 2: 0.603 g / NaH / paraffin; dimethylformamide / 3 h / Ambient temperature 3: 0.370 g / KON / ethanol; H2O / 3 h / Heating 4: 0.249 g / 150 - 160 °C / 15 - 20 Torr 5: 1.663 g / diethyl ether / 2 h / Ambient temperature 6: 1.305 g / LiAlH4 / diethyl ether; tetrahydrofuran / 1.) room temperature, 1 h, 2.) reflux, 1 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 9 p. 2051 - 2058
反应条件
1: 0.603 g / NaH / paraffin; dimethylformamide / 3 h / Ambient temperature 2: 0.370 g / KON / ethanol; H2O / 3 h / Heating 3: 0.249 g / 150 - 160 °C / 15 - 20 Torr 4: 1.663 g / diethyl ether / 2 h / Ambient temperature 5: 1.305 g / LiAlH4 / diethyl ether; tetrahydrofuran / 1.) room temperature, 1 h, 2.) reflux, 1 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 9 p. 2051 - 2058
反应条件
1: 0.249 g / 150 - 160 °C / 15 - 20 Torr 2: 1.663 g / diethyl ether / 2 h / Ambient temperature 3: 1.305 g / LiAlH4 / diethyl ether; tetrahydrofuran / 1.) room temperature, 1 h, 2.) reflux, 1 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 9 p. 2051 - 2058
反应条件
1: 0.370 g / KON / ethanol; H2O / 3 h / Heating 2: 0.249 g / 150 - 160 °C / 15 - 20 Torr 3: 1.663 g / diethyl ether / 2 h / Ambient temperature 4: 1.305 g / LiAlH4 / diethyl ether; tetrahydrofuran / 1.) room temperature, 1 h, 2.) reflux, 1 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 9 p. 2051 - 2058
