3-[4-(苄氧基)苯基]-1-丙醇合成路线 （共 33 条）
反应条件
1: sodium hydride / tetrahydrofuran / 4 h / 0 - 20 °C 2: dichloromethane / 8 h / 20 °C 3: lithium borohydride / water; diethyl ether / 24 h / 0 - 20 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 96, # 2 p. 289 - 295
反应条件
1: 92 percent / diethyl ether / 24 h / Ambient temperature 2: 95 percent / H2 / 10percent Pd/C / ethyl acetate / 3.5 h / 25 °C / 5320 Torr View Scheme
参考文献
Boll, Per M.; Hald, Mogens; Parmar, Virinder S.; Tyagi, Om Dutt; Bisht, Kirpal S.; et al.
Phytochemistry (Elsevier), 1992 , vol. 31, # 3 p. 1035 - 1037
反应条件
1: 45.3 percent / Ag2CO3-celite / benzene / Heating 2: 100 percent / H2 / 10percent Pd-C / methanol / 760 Torr / Ambient temperature View Scheme
参考文献
Herbert, Richard B.; Kattah, Abdullah E.
Tetrahedron, 1990 , vol. 46, # 20 p. 7105 - 7118
反应条件
1: 76 percent / Dess-Martin periodinane / CH2Cl2 / 0 °C 2: CSA / CH2Cl2 / 15 °C 3: 70 percent / InCl3 / CH2Cl2 / 22 h / 0 °C 4: 70 percent / Bu3SnH; 1,1'-azobis(cyclohexane carbonitrile) / benzene / 16 h / Heating 5: H2 / Pd/C / methanol; ethyl acetate / 3 h / 20 °C View Scheme
参考文献
Boulard, Lucie; Bouzbouz, Samir; Cossy, Janine; Franck, Xavier; Figadere, Bruno
Tetrahedron Letters, 2004 , vol. 45, # 35 p. 6603 - 6605
反应条件
hydrogen; palladium on activated charcoal in acetic acid
参考文献
Henley-Smith, Peter; Whiting, Donald A.; Wood, Andrew F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 614 - 622
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran
15 h; from 0 deg C to RT;
参考文献
Menzler, Stefan; Bikker, Jack A.; Horwell, David C.
Tetrahedron Letters, 1998 , vol. 39, # 41 p. 7619 - 7622
反应条件
1: 89 percent / hydrogen / 10percent palladium-carbon / acetic acid
2: 4.08 g / potassium carbonate / acetone / 0.5 h / Heating
View Scheme
参考文献
Henley-Smith, Peter; Whiting, Donald A.; Wood, Andrew F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 614 - 622
反应条件
1: 89 percent / hydrogen / 10percent palladium-carbon / acetic acid
2: 4.08 g / potassium carbonate / acetone / 0.5 h / Heating
3: 51 percent / pyridinium chlorochromate / CH2Cl2
View Scheme
参考文献
Henley-Smith, Peter; Whiting, Donald A.; Wood, Andrew F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 614 - 622
反应条件
1: 79 percent / pyridinium dichromate / CH2Cl2 / 22 h / Ambient temperature
2: 1.) tert-butyllithium / 1.) hexane, pentane, 0 deg C, 4.5h 2.) THF, 2h, 0-10 deg C
3: 92 percent / pyridine / 0.5 h / 100 - 110 °C
4: 87 percent / tetraethylammonium fluoride / tetrahydrofuran / 24 h / Ambient temperature
5: 83 percent / H2 / 10percent Pd/C / ethanol; ethyl acetate / 12 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Ronald, Robert C.; Wheeler, Carl J.
Journal of Organic Chemistry, 1984 , vol. 49, p. 1658 - 1660
反应条件
triethylamine in tetrahydrofuran
1 h;
参考文献
Xue; Voss; Nelson; Duan; Cherney; Jacobson; He; Roderick; Chen; Corbett; Wang; Meyer; Kennedy; Degrado; Hardman; Teleha; Jaffee; Liu; Copeland; Covington; Christ; Trzaskos; Newton; Magolda; Wexler; Decicco
Journal of Medicinal Chemistry, 2001 , vol. 44, # 16 p. 2636 - 2660
