反应条件
1: 3-bromo-5-chloro-2-hydroxypyridine With sodium hydride in tetrahydrofuran; mineral oil
Inert atmosphere;
2: With tert.-butyl lithium in tetrahydrofuran; mineral oil
T=-78 - -65°C;
3: N,N-dimethyl-formamide
参考文献
Chen, Li; Han, Xingchun; Yang, Song; Zhang, Zhuming
Patent: US2010/204257 A1, 2010 ;
Location in patent: Page/Page column 6 ;
