(4R)-4-羟基-L-脯氨酸乙酯合成路线 （共 4 条）
反应条件
1: 100 percent / dimethylformamide; H2O / 2 h / 50 °C 2: LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Ojima, Iwao; Kogure, Tetsuo; Yoda, Noriko
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4728 - 4739
反应条件
1: 96 percent / Et3N; DMAP / CH2Cl2 / 48 h / 20 °C 2: 25 percent / NaBH4 / tetrahydrofuran; ethanol / 2 h / Heating View Scheme
参考文献
Curtis, Kim L.; Fawcett, John; Handa, Sandeep
Tetrahedron Letters, 2005 , vol. 46, # 32 p. 5297 - 5300
反应条件
in water; N,N-dimethyl-formamide
T=50°C; 2 h;
参考文献
Ojima, Iwao; Kogure, Tetsuo; Yoda, Noriko
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4728 - 4739
反应条件
triethylamine in dichloromethane
参考文献
Loenarz, Christoph; Mecinovic, Jasmin; Chowdhury, Rasheduzzaman; McNeill, Luke A.; Flashman, Emily; Schofield, Christopher J.
Angewandte Chemie - International Edition, 2009 , vol. 48, # 10 p. 1784 - 1787
