Boc-反-4-羟基-L-脯氨酸醇合成路线 （共 28 条）
反应条件
lithium borohydride in tetrahydrofuran T=0 - 20°C;
参考文献
Peterson, Mark L.; Vince, Robert
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2787 - 2797
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 4.25 h; 2: With methanol in tetrahydrofuran T=20°C; 62 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2005/103031 A1, 2005 ;
Location in patent: Page/Page column 70-71 ;
WO 2005/103031 A1
反应条件
1: With sodium carbonate in tetrahydrofuran; water T=20°C; 2 h; 2: With 4-methyl-morpholine; isobutyl chloroformate in ethylene glycol dimethyl ether T=-20°C; 0.5 h; 3: With sodium tetrahydroborate in water T=-20°C; 0.5 h;
参考文献
Kyowa Hakko Kirin Co., Ltd.; OTSUBO, Nobumasa; OKAZAKI, Shuko; TSUKUMO, Yukihito; IIDA, Kyoichiro; NAKOJI, Masayoshi
Patent: EP2708540 A1, 2014 ;
Location in patent: Paragraph 0305-0306 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1.) 0 deg C, 1 h, 2.) room temperature, 15 h;
参考文献
Baker, Gregory L.; Fritschel, Scott J.; Stille, John R.; Stille, John K.
Journal of Organic Chemistry, 1981 , vol. 46, # 14 p. 2954 - 2960
反应条件
aq. NaOH in tetrahydrofuran; methanol; dichloromethane; water
参考文献
Syngenta Limited
Patent: US6605630 B1, 2003 ;
反应条件
1: aqueous Na2CO3 / tetrahydrofuran; dioxane / 18 h 2: NMM / 1,2-dimethoxy-ethane / 0.5 h / -20 °C 3: 11.96 g / NaBH4 / 1,2-dimethoxy-ethane; H2O / 0.33 h / Cooling View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 10 p. 3923 - 3931
反应条件
1: aqueous Na2CO3 / tetrahydrofuran; dioxane / 18 h 2: NMM / 1,2-dimethoxy-ethane / 0.5 h / -20 °C 3: 11.96 g / NaBH4 / 1,2-dimethoxy-ethane; H2O / 0.33 h / Cooling View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 10 p. 3923 - 3931
反应条件
1: 75 percent 2: 95 percent / borane-dimethyl-sulfide / tetrahydrofuran / 1.) room temperature, 30 min, 2.) reflux, 2.5 h View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 28, # 1-11 p. 294 - 296
反应条件
1: 75 percent 2: 95 percent / borane-dimethyl-sulfide / tetrahydrofuran / 1.) room temperature, 30 min, 2.) reflux, 2.5 h View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 28, # 1-11 p. 294 - 296
反应条件
1: 69.6 percent / Et3N / dioxane; H2O / 15 h / 50 °C 2: 81 percent / LiAlH4 / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) room temperature, 15 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 14 p. 2954 - 2960
