Boc-反-4-羟基-L-脯氨酸醇合成路线 （共 28 条）
反应条件
hydrogen; palladium dihydroxide in methanol
参考文献
Journal of the Chemical Society, Chemical Communications, , # 23 p. 1527 - 1528
反应条件
1: di-isopropyl azodicarboxylate, Ph3P / tetrahydrofuran / 12 h / -20 °C 2: hydrazine / ethanol / 6 h / Heating 3: Et3N / CH2Cl2 4: 78 percent / I2 / tetrahydrofuran; H2O / 6 h / 20 °C 5: Et3N / CH2Cl2 6: K2CO3 / methanol 7: H2 / Pd(OH)2/C / methanol View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 23 p. 1527 - 1528
反应条件
1: hydrogen / Pd/CaCO3 / ethyl acetate 2: di-isopropyl azodicarboxylate, Ph3P / tetrahydrofuran / 12 h / -20 °C 3: hydrazine / ethanol / 6 h / Heating 4: Et3N / CH2Cl2 5: 78 percent / I2 / tetrahydrofuran; H2O / 6 h / 20 °C 6: Et3N / CH2Cl2 7: K2CO3 / methanol 8: H2 / Pd(OH)2/C / methanol View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 23 p. 1527 - 1528
反应条件
1: Et3N / CH2Cl2 2: 78 percent / I2 / tetrahydrofuran; H2O / 6 h / 20 °C 3: Et3N / CH2Cl2 4: K2CO3 / methanol 5: H2 / Pd(OH)2/C / methanol View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 23 p. 1527 - 1528
反应条件
1: 78 percent / I2 / tetrahydrofuran; H2O / 6 h / 20 °C 2: Et3N / CH2Cl2 3: K2CO3 / methanol 4: H2 / Pd(OH)2/C / methanol View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 23 p. 1527 - 1528
反应条件
1: Et3N / CH2Cl2 2: K2CO3 / methanol 3: H2 / Pd(OH)2/C / methanol View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 23 p. 1527 - 1528
反应条件
1: hydrazine / ethanol / 6 h / Heating 2: Et3N / CH2Cl2 3: 78 percent / I2 / tetrahydrofuran; H2O / 6 h / 20 °C 4: Et3N / CH2Cl2 5: K2CO3 / methanol 6: H2 / Pd(OH)2/C / methanol View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 23 p. 1527 - 1528
反应条件
1: K2CO3 / methanol 2: H2 / Pd(OH)2/C / methanol View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 23 p. 1527 - 1528
反应条件
1: 100 percent / dimethylformamide; H2O / 2 h / 50 °C 2: LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 23 p. 4728 - 4739
反应条件
1: sodium hydrogencarbonate / methanol / 20 °C / |Inert atmosphere 2: lithium borohydride / tetrahydrofuran / 4 h / 20 °C / |Inert atmosphere View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 5, # 1 p. 56 - 60
