1.1: 98 percent / triethylamine / CH2Cl2 / 2 h / 20 °C 2.1: LDA; chlorotrimethylsilane / hexane; tetrahydrofuran / -78 °C 2.2: NBS / tetrahydrofuran; hexane / 0 °C 3.1: 3.38 g / p-TsOH*H2O / ethanol / 2 h / 0 °C 4.1: 70 percent / PCC; sodium acetate; 4 Angstroem MS / CH2Cl2 / 1 h / 20 °C 5.1: 33 percent / Et2Zn / RhCl(PPh3)3 / tetrahydrofuran; hexane / 0 °C View Scheme

1.1: 98 percent / triethylamine / CH2Cl2 / 2 h / 20 °C 2.1: LDA; chlorotrimethylsilane / hexane; tetrahydrofuran / -78 °C 2.2: NBS / tetrahydrofuran; hexane / 0 °C 3.1: 3.38 g / p-TsOH*H2O / ethanol / 2 h / 0 °C 4.1: 70 percent / PCC; sodium acetate; 4 Angstroem MS / CH2Cl2 / 1 h / 20 °C 5.1: 33 percent / Et2Zn / RhCl(PPh3)3 / tetrahydrofuran; hexane / 0 °C View Scheme

1.1: 98 percent / triethylamine / CH2Cl2 / 2 h / 20 °C 2.1: LDA; chlorotrimethylsilane / hexane; tetrahydrofuran / -78 °C 2.2: NBS / tetrahydrofuran; hexane / 0 °C 3.1: 3.38 g / p-TsOH*H2O / ethanol / 2 h / 0 °C 4.1: 70 percent / PCC; sodium acetate; 4 Angstroem MS / CH2Cl2 / 1 h / 20 °C 5.1: 33 percent / Et2Zn / RhCl(PPh3)3 / tetrahydrofuran; hexane / 0 °C View Scheme

sulfuric acid; hydrogen bromide

hydrazine

暂无反应条件数据

(i) (tosylation), (ii) NaI, acetone; Multistep reaction;