反应条件
1.1: potassium carbonate / bis(triphenylphosphine)palladium(II)-chloride / N,N-dimethyl-formamide; water / 24 h / 80 °C
2.1: chloroform / 0.5 h / 20 °C / Inert atmosphere; Cooling with ice
2.2: 3 h / 20 °C / Reflux
3.1: trichlorophosphate / toluene / 18 h / Reflux; Inert atmosphere
View Scheme
参考文献
ROCHE DIAGNOSTICS OPERATIONS, INC.; Cysewski, Robert; de Cola, Luisa; Fernandez Hernandez, Jesus Miguel; Josel, Hans-Peter; Lopez-Calle, Eloisa; Zarnt, Toralf
Patent: US2013/323719 A1, 2013 ;