反应条件
1: 89 percent / tetrahydrofuran / 91 h / Heating 2: 50 percent / triethylamine, Pd(PPh3)2Cl2, CuI / 13 h / 100 °C 3: 1.) tert-butyllithium, 2.) 1,2-dibromoethane / 1.) Et2O, pentane, -20 deg C, 3 h, 2.) Et2O, pentane, -100 deg C to r.t., overnight 4: 77 percent / sodium ethoxide / ethanol / 2 h / Heating View Scheme
参考文献
Glennon, R. A.; Schubert, E.; Jacyno, J. M.; Rosecrans, J. A.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1222 - 1226
