反应条件
1: 1.) Br2, HOAc, 2.) 50percent aq. NaOH / 0.5 h / Ambient temperature 2: 1.) concd. H2SO4, NaNO2 / 1.) HOAc, 15 deg C, 3 h, 2.) H2O, 35-40 deg C, 1 h 3: 40.8 percent / concd. H2SO4 / 3 h / Heating 4: 77.4 percent / concd. HCl, NaNO2, HOAc / H2O / 1.) 5 deg C, 30 min, 2.) 85 deg C, 1 h 5: SOCl2, DMF / 3 h / Heating 6: SOCl2, DMF / 3 h / Heating View Scheme
参考文献
Bochis; Chabala; Harris; Peterson; Barash; Beattie; Brown; Graham; Waksmunski; Tischler; Joshua; Smith; Colwell; Wyvratt Jr.; Fisher; Tamas; Nicolich; Schleim; Wilks et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2843 - 2852
