2,5-二羟基-1,4-苯喹酮合成路线 （共 60 条）
反应条件
1: H2O; air / 95 °C 2: palladium/charcoal; nitrobenzene View Scheme
参考文献
Harley-Mason; Laird
Tetrahedron, 1959 , vol. 7, p. 70,76
反应条件
acetic anhydride T=20 - 100°C; 4 h;
参考文献
Rosenau, Thomas; Mereiter, Kurt; Jaeger, Christian; Schmid, Peter; Kosma, Paul
Tetrahedron, 2004 , vol. 60, # 27 p. 5719 - 5723
参考文献
Maier, Guenther; Schrot, Juergen; Reisenauer, Hans Peter
Chemische Berichte, 1991 , vol. 124, # 11 p. 2613 - 2616
反应条件
1.1: palladium 10 on activated carbon; hydrogen / ethanol / 72 h / 3750.38 Torr 2.1: pyridinium p-toluenesulfonate / toluene / 15 h / |Dean-Stark; |Reflux 3.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -10 °C / |Inert atmosphere 3.2: 0.17 h / -10 - 25 °C / |Inert atmosphere 4.1: hydrogenchloride / 1,4-dioxane; water / 8 h / |Reflux View Scheme
参考文献
Chen, Fanglei; Zhang, Guiping; Hong, Zebin; Lin, Zhonghui; Lei, Min; Huang, Mingdong; Hu, Lihong
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 10 p. 2379 - 2382
反应条件
(i) SOCl2, CHCl3, (ii) /BRN= 1939229/, AcOH; Multistep reaction;
参考文献
Zee-Cheng,K.-Y.; Cheng,C.C.
Journal of Medicinal Chemistry, 1970 , vol. 13, p. 264 - 268
参考文献
Crosby; Lutz
Journal of the American Chemical Society, 1956 , vol. 78, p. 1233
反应条件
dihydrogen peroxide; water-d2 T=39.99°C; 24 h;
参考文献
Hosoya, Takashi; Rosenau, Thomas
Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3176 - 3182
反应条件
acetic acid in ethanol 24 h; Heating;
参考文献
Journal of Materials Chemistry, , vol. 15, # 46 p. 4894 - 4898
反应条件
acetyl chloride T=20 - 90°C; Inert atmosphere;
参考文献
Hanss, David; Walther, Mathieu E.; Wenger, Oliver S.
Chemical Communications, 2010 , vol. 46, # 37 p. 7034 - 7036
反应条件
1: ether BF3 2: diisopropylamine View Scheme
参考文献
Kaji, Akira; Kimura, Kengo; Teranishi, Masanori; Kiriyama, Noriki; Nomura, Masaaki; Miyamoto, Ken-Ichi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 8 p. 1325 - 1329
