反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
2.1: potassium tert-butylate / tetrahydrofuran / 10 °C
2.2: 20 °C / pH 4
3.1: water / dimethyl sulfoxide / 150 °C / Cooling
3.2: 0 °C
4.1: tetrahydrofuran / 60 °C / Inert atmosphere
5.1: potassium carbonate / ethanol / 125 °C / Inert atmosphere
6.1: pyridine; tetraphosphorus decasulfide / 60 °C
View Scheme
参考文献
Duffey, Matthew O.; Vos, Tricia J.; Adams, Ruth; Alley, Jennifer; Anthony, Justin; Barrett, Cynthia; Bharathan, Indu; Bowman, Douglas; Bump, Nancy J.; Chau, Ryan; Cullis, Courtney; Driscoll, Denise L.; Elder, Amy; Forsyth, Nancy; Frazer, Jonathan; Guo, Jianping; Guo, Luyi; Hyer, Marc L.; Janowick, David; Kulkarni, Bheemashankar; Lai, Su-Jen; Lasky, Kerri; Li, Gang; Li, Jing; Liao, Debra; Little, Jeremy; Peng, Bo; Qian, Mark G.; Reynolds, Dominic J.; Rezaei, Mansoureh; Scott, Margaret Porter; Sells, Todd B.; Shinde, Vaishali; Shi, Qiuju Judy; Sintchak, Michael D.; Soucy, Francois; Sprott, Kevin T.; Stroud, Stephen G.; Nestor, Michelle; Visiers, Irache; Weatherhead, Gabriel; Ye, Yingchun; Damore, Natalie
Journal of Medicinal Chemistry, 2012 , vol. 55, # 1 p. 197 - 208