2,2-二甲基-1-苯丙胺合成路线 （共 19 条）
反应条件
1: With copper(I) bromide in tetrahydrofuran 24 h; Heating; 2: With sodium tetrahydroborate in tetrahydrofuran; methanol T=-78 - 20°C; Further stages.;
参考文献
Kuendig, E. Peter; Seidel, Thomas M.; Jia, Yi-Xia; Bernardinelli, Gerald
Angewandte Chemie - International Edition, 2007 , vol. 46, # 44 p. 8484 - 8487
参考文献
Dunina; Kazakova; Grishin; Malyshev
Russian Chemical Bulletin, 1997 , vol. 46, # 7 p. 1321 - 1330
反应条件
in tetrahydrofuran T=-70 - 0°C; 2 h;
参考文献
Hart, David J.; Kanai, Ken-ichi; Thomas, Dudley G.; Yang, Teng-Kuei
Journal of Organic Chemistry, 1983 , vol. 48, # 3 p. 289 - 294
反应条件
(i) <NH4>2CO3, aq. HCO2H, (ii) aq. HCl; Multistep reaction;
参考文献
Tetrahedron, , vol. 21, p. 3263 - 3272
反应条件
in tetrahydrofuran 18 h; Heating;
参考文献
Hart, David J.; Kanai, Ken-ichi; Thomas, Dudley G.; Yang, Teng-Kuei
Journal of Organic Chemistry, 1983 , vol. 48, # 3 p. 289 - 294
反应条件
potassium cyanide; sulfuric acid in anhydrous butyl ether T=60 - 80°C;
参考文献
Bulletin de la Societe Chimique de France, , p. 2319 - 2324
反应条件
1: 89 percent / 1) n-butyllithium / 1) 5 min, 2) 10 min, ice bath 2: 66 percent / tetrahydrofuran / 18 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 3 p. 289 - 294
反应条件
in tetrahydrofuran; hexane T=-80°C; 1 h; Yield given;
参考文献
Tetrahedron Letters, , vol. 33, # 5 p. 627 - 630
反应条件
1: 80 percent / sodium azide / dimethylsulfoxide / 72 h / 25 °C 2: 100 percent / diethyl ether / 3 h / Ambient temperature 3: 1.) PPh3 / 1.) Et2), RT, 4 h, 2.) Et2O, RT, overnight 4: 1.) aq. KOH, 2.) 10percent aq. HCl / 1.) EtOH, RT, 1 h, 2.) EtOH, reflux, 2 h View Scheme
参考文献
Synthetic Communications, , vol. 24, # 20 p. 2955 - 2972
反应条件
1: 2.) SOCl2 / 1.) benzene, 25 deg C, 30 min, 2.) benzene, 25 deg C, 20 h 2: 80 percent / sodium azide / dimethylsulfoxide / 72 h / 25 °C 3: 100 percent / diethyl ether / 3 h / Ambient temperature 4: 1.) PPh3 / 1.) Et2), RT, 4 h, 2.) Et2O, RT, overnight 5: 1.) aq. KOH, 2.) 10percent aq. HCl / 1.) EtOH, RT, 1 h, 2.) EtOH, reflux, 2 h View Scheme
参考文献
Synthetic Communications, , vol. 24, # 20 p. 2955 - 2972
