2-氧代-1-吡咯烷乙酸乙酯合成路线 （共 41 条）
反应条件
1: CH2Cl2 / 6 h 2: 1) NaOMe / 1) MeOH, 0 deg C, 3 h; 2) MeOH, heating, 2 h 3: 73 percent / H2 / Raney nickel / ethanol / 4 h / 2327.2 Torr View Scheme
参考文献
Jain, Sanjay; Sujatha; Rama Krishna; Roy, Raja; Singh, Jujhar; Anand, Nitya
Tetrahedron, 1992 , vol. 48, # 23 p. 4985 - 4998
参考文献
Kadushkin, A. V.; Golovko, T. V.; Granik, V. G.; Glushkov, R. G.; Parimbetova, R. B.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 10 p. 803 - 806
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 10 p. 1193 - 1196
反应条件
sodium in toluene
1.) reflux, 1 h, 2.) reflux, 1 h;
参考文献
Knight, David W.; Lewis, Neil; Share, Andrew C.; Haigh, David
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 22 p. 3673 - 3683
反应条件
N-benzyl-trimethylammonium hydroxide
T=20°C; Neat (no solvent); chemoselective reaction;
参考文献
Meshram; Reddy, B. Chennakesava; Goud, P. Ramesh
Synthetic Communications, 2009 , vol. 39, # 13 p. 2297 - 2303
反应条件
hydrogen; barium sulfate; palladium on activated charcoal in ethyl acetate
P=7500.6 Torr; 18 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Laffan; Banziger; Duc; Evans; McGarrity; Meul
Helvetica Chimica Acta, 1992 , vol. 75, # 3 p. 892 - 900
反应条件
ethylmagnesium bromide in diethyl ether
T=-40°C; 0.5 h;
参考文献
Shipov, A. G.; Zheltonogova, E. A.; Kobzareva, V. P.; Orlova, N. A.; Baukov, Yu. I.
J. Gen. Chem. USSR (Engl. Transl.), 1991 , vol. 61, # 10 p. 2308 - 2317,2142 - 2150
反应条件
dimethylmono-chlorosilane; tin(IV) chloride in dichloromethane
2 h; Heating;
参考文献
Shipov, A. G.; Zheltonogova, E. A.; Kobzareva, V. P.; Orlova, N. A.; Baukov, Yu. I.
J. Gen. Chem. USSR (Engl. Transl.), 1991 , vol. 61, # 10 p. 2308 - 2317,2142 - 2150
反应条件
hydrogen; platinum on activated charcoal
Yield given;
参考文献
Laffan; Banziger; Duc; Evans; McGarrity; Meul
Helvetica Chimica Acta, 1992 , vol. 75, # 3 p. 892 - 900
反应条件
trimethylsilyl bromide
T=155 - 165°C; 3.5 h;
参考文献
Kramarova, E. P.; Shipov, A. G.; Orlova, N. A.; Artamkina, O. B.; Belavin, I. Yu.; Baukov, Yu. I.
J. Gen. Chem. USSR (Engl. Transl.), 1988 , vol. 58, # 5 p. 1093 - 1102,970 - 979
反应条件
dimethylmono-chlorosilane; tin(IV) chloride
1.) heating, 2 h, 2.) CH2Cl2, heating, 1 h; Yield given. Multistep reaction;
参考文献
Shipov, A. G.; Zheltonogova, E. A.; Kobzareva, V. P.; Orlova, N. A.; Baukov, Yu. I.
J. Gen. Chem. USSR (Engl. Transl.), 1991 , vol. 61, # 10 p. 2308 - 2317,2142 - 2150
