1-苄氧基-3-甲基-2-硝基苯合成路线 （共 19 条）
反应条件
potassium carbonate in acetonitrile Heating / reflux;
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US2004/186114 A1, 2004 ;
Location in patent: Page/Page column 53; 54 ;
反应条件
in N,N-dimethyl-formamide
反应条件
1: trimethyl-sulfonium iodide With sodium hydride in N,N-dimethyl-formamide; paraffin oil Cooling with iceInert atmosphere; 2: 1-Nitro-2-(phenylmethoxy)benzene in N,N-dimethyl-formamide; paraffin oil T=20°C; 16 h; Cooling with iceInert atmosphere;
参考文献
Haiss, Peter; Zeller, Klaus-Peter
European Journal of Organic Chemistry, 2011 , # 2 p. 295 - 301
反应条件
1: (nitration) 2: NaH / tetrahydrofuran; dimethylformamide View Scheme
参考文献
Australian Journal of Chemistry, , vol. 29, p. 2003 - 2021
反应条件
1: potassium ethylate; diethyl ether / Erwaermen des Reaktionsprodukts mit wss. Natronlauge 2: FeSO4; aqueous NH3 3: palladium/charcoal; methanol / Hydrogenation View Scheme
参考文献
Beer et al.
Journal of the Chemical Society, 1948 , p. 1605,1608
反应条件
1: dimethylformamide / 5 h / Heating 2: 9.8 g / 2N aq. HCl / diisopropyl ether / 0.17 h / 0 - 20 °C 3: 80 percent / H2 / 10 percent Pd-C / ethanol / 2 h / 20 °C / 2206.52 Torr View Scheme
参考文献
Beer et al.
Journal of the Chemical Society, 1948 , p. 1605,1608
反应条件
1: With pyrrolidine in DMF (N,N-dimethyl-formamide) T=110°C; 3 h; Under N2; 2: With hydrogen; palladium on activated carbon; palladium on activated charcoal in methanol; acetic acid T=20°C; P=2585.81 Torr; 2 h;
参考文献
Orme, Mark W.; Sawyer, Jason Scott; Daugan, Alain Claude-Marie
Patent: US2003/225092 A1, 2003 ;
Location in patent: Page 19 ;
反应条件
1: With pyrrolidine in N,N-dimethyl-formamide T=20°C; Inert atmosphereReflux; 2: With iron; ammonium chloride in ethanol; water T=20°C; Inert atmosphereReflux;
参考文献
Ueda, Hirofumi; Satoh, Hitoshi; Sugimoto, Kenji; Tokuyama, Hidetoshi; Matsumoto, Koji; Fukuyama, Tohru
Angewandte Chemie, International Edition, 2009 , vol. 48, # 41 p. 7600 - 7603
反应条件
1: dimethylformamide / 5 h / Heating 2: 9.8 g / 2N aq. HCl / diisopropyl ether / 0.17 h / 0 - 20 °C 3: 76 percent / NH4Cl; Fe / H2O; ethanol / 1 h / Heating View Scheme
参考文献
Harada, Hiroshi; Fujii, Akihito; Kato, Shiro
Synthetic Communications, 2003 , vol. 33, # 3 p. 507 - 514
反应条件
1: With iron; ammonium chloride in methanol; water
T=95°C; 16 h;
2: With sodium hydroxide in water
参考文献
Bristol-Myers Squibb Company
Patent: US2007/49577 A1, 2007 ;
Location in patent: Page/Page column 13 ;
US 20070049577 A1
