ammonia; silver trifluoromethanesulfonate in methanol T=120°C; 1 h; Microwave irradiationsealed tube; regioselective reaction;

1.1: tetrahydrofuran / 0 - 5 °C 2.1: chromium(VI) oxide / acetone / -70 - 25 °C 3.1: trans-PdCl2(PPh3)2; triethylamine / 0.25 h / 20 °C / Inert atmosphere 3.2: 1 h / 80 °C / Inert atmosphere 4.1: ammonia; silver trifluoromethanesulfonate / methanol / 1 h / 120 °C / Microwave irradiation; sealed tube View Scheme

1.1: chromium(VI) oxide / acetone / -70 - 25 °C 2.1: trans-PdCl2(PPh3)2; triethylamine / 0.25 h / 20 °C / Inert atmosphere 2.2: 1 h / 80 °C / Inert atmosphere 3.1: ammonia; silver trifluoromethanesulfonate / methanol / 1 h / 120 °C / Microwave irradiation; sealed tube View Scheme

1.1: trans-PdCl2(PPh3)2; triethylamine / 0.25 h / 20 °C / Inert atmosphere 1.2: 1 h / 80 °C / Inert atmosphere 2.1: ammonia; silver trifluoromethanesulfonate / methanol / 1 h / 120 °C / Microwave irradiation; sealed tube View Scheme

1: 94 percent / 30percent H2O2 / acetic acid / 12 h / 75 °C 2: 77 percent / 3.5 h / 100 °C View Scheme

chloroform; phosphorus trichoride

1: 77 percent / 3.5 h / 100 °C View Scheme

Yield given. Multistep reaction. Yields of byproduct given;