N-{[(2-甲基-2-丙基)氧基]羰基}-L-苯丙氨酰-L-蛋氨酸合成路线 （共 7 条）
反应条件
1: 2N HCl / acetic acid / 0.33 h 2: 1.) 4-hydroxy-3-nitrobenzophenone fixed to a polystyrene matrix, 2.) triethylamine / 2.) DMF, 20 min 3: 2N HCl / acetic acid 4: 1.) 4-hydroxy-3-nitrobenzophenone fixed to a polystyrene matrix, 2.) triethylamine / 2.) DMF, 30 min 5: 85 percent / 2N HCl / acetic acid / 0.5 h View Scheme
参考文献
Grigor'ev, E. I.; Chernova, S. V.
Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 468 - 474
反应条件
sulfuric acid; sodium hydrogencarbonate in diethyl ether; water; ethyl acetate; acetonitrile
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4358440 A1, 1982 ;
反应条件
sodium hydroxide in 1,4-dioxane; water
1 h; Ambient temperature;
参考文献
Van Nispen; Greven
Recueil des Travaux Chimiques des Pays Bas, 1982 , vol. 101, # 12 p. 451 - 455
反应条件
sodium hydroxide in 1,4-dioxane
24 h; Ambient temperature;
参考文献
Grigor'ev, E. I.; Chernova, S. V.
Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 468 - 474
反应条件
sodium hydroxide; sodium hydrogencarbonate in N,N-dimethyl-formamide
T=-5°C; Yield given;
参考文献
Bobrova, Irina; Abissova, Natalia; Mishlakova, Natalia; Rozentals, Guntis; Chipens, Gunar
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 4 p. 255 - 266
反应条件
(i) <PhCH2NMe3>OH, (ii) /BRN= 715573/; Multistep reaction;
参考文献
Wang,S.-S. et al.
Journal of Organic Chemistry, 1977 , vol. 42, p. 1286 - 1290
反应条件
1: 2N HCl / acetic acid / 0.33 h
2: 1.) 4-hydroxy-3-nitrobenzophenone fixed to a polystyrene matrix, 2.) triethylamine / 2.) DMF, 20 min
3: 2N HCl / acetic acid
4: 1.) 4-hydroxy-3-nitrobenzophenone fixed to a polystyrene matrix, 2.) triethylamine / 2.) DMF, 30 min
View Scheme
参考文献
Grigor'ev, E. I.; Chernova, S. V.
Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 468 - 474
