1: With borane-THF in tetrahydrofuran T=20°C; 18 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=1; 4 h; 3: With sodium hydroxide in tetrahydrofuran; water pH=> 10;

1: With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide in dichloromethane T=20°C; 0.75 h; 2: With ammonia in dichloromethane T=0 - 20°C;

ammonia in tetrahydrofuran T=0 - 20°C;