2-(5-溴-2-氟苯基)-1-乙胺合成路线 （共 3 条）
反应条件
sodium tetrahydroborate; nickel dichloride in methanol
参考文献
Malancona, Savina; Colarusso, Stefania; Ontoria, Jesus M.; Marchetti, Antonella; Poma, Marco; Stansfield, Ian; Laufer, Ralph; Di Marco, Annalise; Taliani, Marina; Verdirame, Maria; Gonzalez-Paz, Odalys; Matassa, Victor G.; Narjes, Frank
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4575 - 4579
反应条件
1: KF; NMM / propan-2-ol / 0 °C
2: Ac2O; NaOAc / 60 °C
3: NaBH4; SiO2 / propan-2-ol; CHCl3
4: NaBH4; NiCl2 / methanol
View Scheme
参考文献
Malancona, Savina; Colarusso, Stefania; Ontoria, Jesus M.; Marchetti, Antonella; Poma, Marco; Stansfield, Ian; Laufer, Ralph; Di Marco, Annalise; Taliani, Marina; Verdirame, Maria; Gonzalez-Paz, Odalys; Matassa, Victor G.; Narjes, Frank
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4575 - 4579
反应条件
1.1: LDA / tetrahydrofuran / 1 h / -78 °C
1.2: 83 percent / tetrahydrofuran
2.1: KF; NMM / propan-2-ol / 0 °C
3.1: Ac2O; NaOAc / 60 °C
4.1: NaBH4; SiO2 / propan-2-ol; CHCl3
5.1: NaBH4; NiCl2 / methanol
View Scheme
参考文献
Malancona, Savina; Colarusso, Stefania; Ontoria, Jesus M.; Marchetti, Antonella; Poma, Marco; Stansfield, Ian; Laufer, Ralph; Di Marco, Annalise; Taliani, Marina; Verdirame, Maria; Gonzalez-Paz, Odalys; Matassa, Victor G.; Narjes, Frank
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4575 - 4579
