(2,3-二氢-[1,4]二噁英o[2,3-b]吡啶-6-基)甲醇合成路线 （共 7 条）
反应条件
manganese(IV) oxide in dichloromethane T=20°C; 15 h;
参考文献
SMITHKLINE BEECHAM P.L.C.
Patent: WO2003/87098 A1, 2003 ;
Location in patent: Page/Page column 60 ;
反应条件
sodium hydroxide; water in tetrahydrofuran
T=20°C; 12 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/14361 A1, 2004 ;
Location in patent: Page/Page column 37 ;
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 0 - 90 °C
2: sodium hydride; copper; copper(II) sulfate / N,N-dimethyl-formamide; mineral oil / 0 - 100 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
4: 5 h / Reflux
5: sodium hydroxide; water / methanol / 1 h / 0 - 20 °C
View Scheme
参考文献
Bhattacharya, Samit K.; Cameron, Kimberly O.; Fernando, Dilinie P.; McClure, Kim F.; Kung, Daniel W.; Londregan, Allyn T.; Simila, Suvi T. M.
Patent: US2011/230461 A1, 2011 ;
US 20110230461 A1
反应条件
1.1: potassium carbonate / water / 0.5 h / 20 °C
1.2: 4 h / 20 °C
2.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 90 °C
3.1: sodium hydride; copper; copper(II) sulfate / N,N-dimethyl-formamide; mineral oil / 0 - 100 °C
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
5.1: 5 h / Reflux
6.1: sodium hydroxide; water / methanol / 1 h / 0 - 20 °C
View Scheme
参考文献
Bhattacharya, Samit K.; Cameron, Kimberly O.; Fernando, Dilinie P.; McClure, Kim F.; Kung, Daniel W.; Londregan, Allyn T.; Simila, Suvi T. M.
Patent: US2011/230461 A1, 2011 ;
US 20110230461 A1
反应条件
1: 5 h / Reflux
2: sodium hydroxide; water / methanol / 1 h / 0 - 20 °C
View Scheme
参考文献
Bhattacharya, Samit K.; Cameron, Kimberly O.; Fernando, Dilinie P.; McClure, Kim F.; Kung, Daniel W.; Londregan, Allyn T.; Simila, Suvi T. M.
Patent: US2011/230461 A1, 2011 ;
US 20110230461 A1
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
2: 5 h / Reflux
3: sodium hydroxide; water / methanol / 1 h / 0 - 20 °C
View Scheme
参考文献
Bhattacharya, Samit K.; Cameron, Kimberly O.; Fernando, Dilinie P.; McClure, Kim F.; Kung, Daniel W.; Londregan, Allyn T.; Simila, Suvi T. M.
Patent: US2011/230461 A1, 2011 ;
US 20110230461 A1
反应条件
1: sodium hydride; copper; copper(II) sulfate / N,N-dimethyl-formamide; mineral oil / 0 - 100 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
3: 5 h / Reflux
4: sodium hydroxide; water / methanol / 1 h / 0 - 20 °C
View Scheme
参考文献
Bhattacharya, Samit K.; Cameron, Kimberly O.; Fernando, Dilinie P.; McClure, Kim F.; Kung, Daniel W.; Londregan, Allyn T.; Simila, Suvi T. M.
Patent: US2011/230461 A1, 2011 ;
US 20110230461 A1
