7,8-二氯-1,2,3,4-四氢异喹啉合成路线 （共 6 条）
反应条件
hydrogen; platinum(IV) oxide in methanol
T=25°C; P=3102.9 Torr;
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
反应条件
1: 100 percent / benzene / Heating
2: concd. H2SO4 / 0.5 h / 140 - 150 °C
3: H2 / PtO2 / methanol / 25 °C / 3102.9 Torr
View Scheme
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
反应条件
1: concd. H2SO4 / 0.5 h / 140 - 150 °C
2: H2 / PtO2 / methanol / 25 °C / 3102.9 Torr
View Scheme
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
反应条件
Fremy’s salt; sodium carbonate
T=25°C; 24 h;
参考文献
Ali; Gleason; Hill; Krell; Kruse; Lavanchy; Volpe
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1235 - 1240
反应条件
1: acetic anhydride / acetic acid / 1 h / Heating
2: 16.7 g / 12 N HCl / 4 h / Heating
View Scheme
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
反应条件
acetic anhydride in acetic acid
1 h; Heating; Yield given;
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
