甲基-2 -(4-异丁基苯基)丙酸合成路线 （共 47 条）
反应条件
sodium hydroxide T=80°C; 2 h;
参考文献
Patil; Wadia
Synthetic Communications, 2002 , vol. 32, # 18 p. 2821 - 2827
参考文献
The Upjohn Company
Patent: US4107439 A1, 1978 ;
反应条件
buffer pH 7.4 in methanol; water T=37°C; half-life time; also in human plasma;
参考文献
Bansal; Khar; Dubey; Sharma
Pharmazie, 1994 , vol. 49, # 6 p. 422 - 424
反应条件
benzophenone in water; acetonitrile T=20°C; 15 h; Irradiation; chemoselective reaction;
参考文献
Chemical Science, , vol. 4, # 8 p. 3118 - 3123
反应条件
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / -78 - 0 °C
1.2: 1 h / 0 °C
2.1: N-benzyl-trimethylammonium hydroxide / methanol; water / 3.5 h / 75 °C
View Scheme
参考文献
Windsor, Matthew A.; Hermanson, Daniel J.; Kingsley, Philip J.; Xu, Shu; Crews, Brenda C.; Ho, Winnie; Keenan, Catherine M.; Banerjee, Surajit; Sharkey, Keith A.; Marnett, Lawrence J.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 9 p. 759 - 763
反应条件
1: caesium carbonate; triethyl phosphite; oxygen / dimethyl sulfoxide / 24 h / 25 °C / 760.05 Torr / |Schlenk technique
2: ethanol; potassium hydroxide / 4 h / 20 °C
View Scheme
参考文献
Liang, Yu-Feng; Jiao, Ning
Angewandte Chemie - International Edition, 2014 , vol. 53, # 2 p. 548 - 552
Angew. Chem., 2014 , vol. 53, # 2 p. 558 - 562,5
反应条件
1: NaBH4, CaCl2 / ethanol / -20 °C
2: 1) oxalyl chloride, DMSO, 2) Et3N / 1) -65 deg C, CH2Cl2, 5 min
View Scheme
参考文献
Chiarino; Ferrario; Pellacini; Sala
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 3 p. 589 - 593
