1: 2 M HCl / 30 h / 50 °C 2: 1) DAPA, MnO2; 2) 0.3 M HCl / 1) benzene, pyridine, 3 h; 2) benzene, AcOEt, 40 min. View Scheme

<b>Multi-step reaction with 5 steps<br /> </b>1: 98 percent / m-chloroperbenzoic acid / CHCl₃ / Ambient temperature<br />2: 98 percent / CHCl₃ / 50 &deg;C<br />3: 83 percent / CH₃ONa / methanol<br />4: 91 percent / SOCl₂ / 0.5 h<br />5: NaOEt / ethanol / overnight<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 98 percent / CHCl₃ / 50 &deg;C<br />2: 83 percent / CH₃ONa / methanol<br />3: 91 percent / SOCl₂ / 0.5 h<br />4: NaOEt / ethanol / overnight<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 83 percent / CH₃ONa / methanol<br />2: 91 percent / SOCl₂ / 0.5 h<br />3: NaOEt / ethanol / overnight<br /> <br /> &nbsp;

<b>Multi-step reaction with 7 steps<br /> </b>1: 1) HCl; 2) NaHCO₃ / 2) H₂O<br />2: 93 percent / pyridine / Ambient temperature<br />3: 98 percent / m-chloroperbenzoic acid / CHCl₃ / Ambient temperature<br />4: 98 percent / CHCl₃ / 50 &deg;C<br />5: 83 percent / CH₃ONa / methanol<br />6: 91 percent / SOCl₂ / 0.5 h<br />7: NaOEt / ethanol / overnight<br /> <br /> &nbsp;