1-(2-氯苯基)-2,2-二甲基-1-丙酮合成路线 （共 8 条）
反应条件
1: 1-bromo-2-chloro-benzene With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran
T=-15°C; 2.5 h;
2: in tetrahydrofuran
T=-20°C; 0.166667 h;
3: pivaloyl chloride in tetrahydrofuran
T=-10°C; 20 h; Further stages.;
参考文献
Korn, Tobias J.; Schade, Matthias A.; Cheemala, Murthy N.; Wirth, Stefan; Guevara, Simon A.; Cahiez, Gerard; Knochel, Paul
Synthesis, 2006 , # 21 p. 3547 - 3574
反应条件
1: tert-butylmagnesium bromide With CuCN*2LiCl in tetrahydrofuran
T=-40°C; 0.25 h;
2: o-chloro benzoic acid chloride in tetrahydrofuran
T=-40 - -5°C;
参考文献
Cahiez, Gerard; Luart, Denis; Lecomte, Fabien
Organic Letters, 2004 , vol. 6, # 24 p. 4395 - 4398
反应条件
potassium fluoride; 18-crown-6 ether in tetrahydrofuran
T=0°C; 10 h;
参考文献
Yoshida, Hiroto; Mimura, Yasuhiro; Ohshita, Joji; Kunai, Atsutaka
Chemical Communications, 2007 , # 23 p. 2405 - 2407
反应条件
dipotassium peroxodisulfate; N-chloro-succinimide; trifluorormethanesulfonic acid; palladium diacetate in 1,2-dichloro-ethane
T=80°C; 8 h; Sealed tube; regioselective reaction;
参考文献
Sun, Xiuyun; Shan, Gang; Sun, Yonghui; Rao, Yu
Angewandte Chemie - International Edition, 2013 , vol. 52, # 16 p. 4440 - 4444
Angew. Chem., 2013 , vol. 125, # 16 p. 4536 - 4540,5
反应条件
Fe2(S04)3 in hexane
T=20°C; Friedel-Crafts acylation; 0.75 h; Sonication;
参考文献
Sridharan, Anandhi; Gopalakrishnan, Geetha
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2011 , vol. 50, # 9 p. 1192 - 1195
反应条件
1: 1-(2-chlorophenyl)ethan-1-one With potassium hydride in tetrahydrofuran
T=0°C; 0.166667 h; Inert atmosphere;
2: methyl iodide in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Rousseaux, Sophie; Davi, Michael; Sofack-Kreutzer, Julien; Pierre, Cathleen; Kefalidis, Christos E.; Clot, Eric; Fagnou, Keith; Baudoin, Olivier
Journal of the American Chemical Society, 2010 , vol. 132, # 31 p. 10706 - 10716
反应条件
palladium diacetate; caesium carbonate; PCy3∙HBF4; 2,2,2-trimethylacetic acid in 1,3,5-trimethyl-benzene
T=140°C; 16 h; Inert atmosphere;
参考文献
Rousseaux, Sophie; Davi, Michael; Sofack-Kreutzer, Julien; Pierre, Cathleen; Kefalidis, Christos E.; Clot, Eric; Fagnou, Keith; Baudoin, Olivier
Journal of the American Chemical Society, 2010 , vol. 132, # 31 p. 10706 - 10716
反应条件
1: diethyl ether
2: aq. HI, phosphorus
View Scheme
参考文献
Bickelhaupt,F. et al.
Tetrahedron, 1976 , vol. 32, p. 1921 - 1930
