反应条件
1: 3-methyl thiophene With 2,2,6,6-tetramethyl-piperidine; isopropylmagnesium chloride in tetrahydrofuran T=66°C; Inert atmosphere; 2: formaldehyd in tetrahydrofuran T=0°C; 2 h; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran; water pH=5; regioselective reaction;
参考文献
Asselin, Sylvie M.; Bio, Matthew M.; Langille, Neil F.; Ngai, Ka Yi
Organic Process Research and Development, 2010 , vol. 14, # 6 p. 1427 - 1431