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乙二醇
甲醛
63148-62-9
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丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
2-吡咯烷酮
合成路线
(共 458 条)
616-45-5
2-吡咯烷酮
+
89080-71-7
→
反应条件
121021-88-3
+
134256-08-9
反应条件
potassium tert-butylate 2.) 100 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Buckle, Derek R.; Houge-Frydrych, Catherine S. V.; Pinto, Ivan L.; Smith, David G.; Tedder, John M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 1 p. 63 - 70
616-45-5
2-吡咯烷酮
+
106-95-6
3-溴丙烯
→
反应条件
2687-97-0
反应条件
1: pyrrolidin-2-one With sodium hydride in tetrahydrofuran 2: allyl bromide in tetrahydrofuran
参考文献
Ohmura, Naoya; Nakamura, Asami; Hamasaki, Akiyuki; Tokunaga, Makoto
European Journal of Organic Chemistry, 2008 , # 30 p. 5042 - 5045
616-45-5
2-吡咯烷酮
+
92954-34-2
→
反应条件
2687-97-0
反应条件
bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide T=60°C; 1 h;
参考文献
Inoue, Yoshio; Taguchi, Masaaki; Hashimoto, Harukichi
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 9 p. 2721 - 2722
616-45-5
2-吡咯烷酮
+
107-18-6
→
反应条件
2687-97-0
反应条件
silver hexafluoroantimonate; ClAu(di(tert-butyl)(1,1′-biphenyl-2-yl)-phosphine) in 1,4-dioxane T=80°C; 48 h; Inert atmosphere;
参考文献
Mukherjee, Paramita; Widenhoeferst, Ross A.
Organic Letters, 2010 , vol. 12, # 6 p. 1184 - 1187
616-45-5
2-吡咯烷酮
→
反应条件
2687-97-0
反应条件
sodium methylate in water; toluene
参考文献
Shin-Etsu Chemical Co., Ltd.
Patent: US5081260 A1, 1992 ;
616-45-5
2-吡咯烷酮
+
556-56-9
→
反应条件
2687-97-0
反应条件
1: pyrrolidin-2-one With sodium hydride in tetrahydrofuran; paraffin oil T=0°C; 0.5 h; Inert atmosphere; 2: 3-iodoprop-1-ene in tetrahydrofuran; paraffin oil T=0 - 20°C; Inert atmosphere;
参考文献
Curti, Claudio; Ranieri, Beatrice; Battistini, Lucia; Rassu, Gloria; Zambrano, Vincenzo; Pelosi, Giorgio; Casiraghi, Giovanni; Zanardi, Franca
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 11-12 p. 2011 - 2022
616-45-5
2-吡咯烷酮
+
107-05-1
→
反应条件
2687-97-0
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; caesium carbonate; tris(p-fluoro phenyl)phosphine in dichloromethane T=20°C; Tsuji-Trost allylation;
参考文献
Aoyagi, Kouichi; Nakamura, Hiroyuki; Yamamoto, Yoshinori
Journal of Organic Chemistry, 2002 , vol. 67, # 17 p. 5977 - 5980
616-45-5
2-吡咯烷酮
+
78-77-3
→
反应条件
2687-92-5
反应条件
potassium hydroxide; tetrabutylammomium bromide in toluene 7 h; Heating;
参考文献
Tahara; Hayano; Murakami; Fukuda; Setoguchi; Ik eda; Marubayashi
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 6 p. 1609 - 1615
616-45-5
2-吡咯烷酮
→
反应条件
2401-40-3
反应条件
Sodium bromate; sulfuric acid; hydrogen bromide in water 1 h; Ambient temperature;
参考文献
Fujisaki, Shizuo; Hamura, Satoshi; Eguchi, Hisao; Nishida, Akiko
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 8 p. 2426 - 2428
616-45-5
2-吡咯烷酮
+
13139-86-1
→
反应条件
22217-80-7
反应条件
1: pyrrolidin-2-one With chloro-trimethyl-silane; triethylamine in diethyl ether 0.5 h; Heating; 2: 4-methoxyphenyl magnesium bromide in diethyl ether 3 h; Heating;
参考文献
Coindet, Cecile; Comel, Alain; Kirsch, Gilbert
Tetrahedron Letters, 2001 , vol. 42, # 35 p. 6101 - 6104
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