4,6-二硝基-1,3-二甲苯合成路线 （共 35 条）
反应条件
2: 87 percent / FeSO4*7H2O, conc. HCl / H2O; ethanol; liquid ammonia / 1 h / 80 °C
3: 97 percent / 2 N NaOH / ethanol; H2O / 1) 80 deg C, 4 h, 2) 2 h, reflux
4: 78 percent / 100percent H2SO4 / 3 h / Heating
View Scheme
参考文献
Quast, Helmut; Schoen, Norbert
Liebigs Annalen der Chemie, 1984 , # 1 p. 133 - 146
反应条件
2: 87 percent / FeSO4*7H2O, conc. HCl / H2O; ethanol; liquid ammonia / 1 h / 80 °C
3: 58 percent / 10percent KOH / ethanol / 3 h / 90 - 100 °C
4: 42 percent / diethyl ether / 26 h / 20 °C
View Scheme
参考文献
Quast, Helmut; Schoen, Norbert
Liebigs Annalen der Chemie, 1984 , # 1 p. 133 - 146
反应条件
1: HNO3+H2SO4
2: tin dichloride; hydrochloric acid
View Scheme
参考文献
Grevingk
Chemische Berichte, 1884 , vol. 17, p. 2423
反应条件
1: concentrated sulfuric acid; chromium (VI)-oxide / <20
2: thionyl chloride
3: AlCl3
View Scheme
参考文献
Ruggli; Schmid
Helvetica Chimica Acta, 1935 , vol. 18, p. 247,253
反应条件
sulfuric acid; nitric acid
参考文献
Martinsen
Zeitschrift fuer Physikalische Chemie, Stoechiometrie und Verwandtschaftslehre, 1907 , vol. 59, p. 618
参考文献
Brand; Mahr
Journal fuer Praktische Chemie (Leipzig), 1935 , vol. <2> 142, p. 153,166
反应条件
sulfuric acid; nitric acid in water
1 h;
参考文献
Zhang, Aimin; Han, Yaohua; Yamato, Kazuhiro; Zeng, Xiao Cheng; Gong, Bing
Organic Letters, 2006 , vol. 8, # 5 p. 803 - 806
反应条件
nitric acid
T=20°C; 16 h; Yields of byproduct given;
参考文献
Quast, Helmut; Schoen, Norbert
Liebigs Annalen der Chemie, 1984 , # 1 p. 133 - 146
反应条件
nitrogen(IV) oxide; ozone; methanesulfonic acid in dichloromethane
T=-10 - 0°C; 9 h;
参考文献
Suzuki, Hitomi; Murashima, Takashi; Kozai, Iku; Mori, Tadashi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 14 p. 1591 - 1598
反应条件
nitric acid
T=20°C; 1 h;
参考文献
Havlik, Martin; Kral, Vladimir; Dolensky, Bohumil
Organic Letters, 2006 , vol. 8, # 21 p. 4867 - 4870
