2-氨基-5-硝基苯甲酸合成路线 （共 87 条）
反应条件
sodium azide; ammonium chloride; trichlorophosphate; N,N-dimethyl-formamide T=0 - 20°C; Curtius rearrangement;
参考文献
Sridhar, Radhakrishnan; Perumal, Paramasivan T.
Synthetic Communications, 2004 , vol. 34, # 4 p. 735 - 742
反应条件
1: With hydrogenchloride; sodium hydroxide; sodium nitrite in water T=0°C; 0.5 h; 2: With potassium iodide in water T=0 - 20°C; 13 h;
参考文献
Cui, Li-Qian; Dong, Zhi-Lei; Liu, Kai; Zhang, Chi
Organic Letters, 2011 , vol. 13, # 24 p. 6488 - 6491
反应条件
sulfur dioxide; water Diazotization.anschliessend Behandeln mit wss. Salzsaeure;
参考文献
Pfannstiel; Janecke
Chemische Berichte, 1942 , vol. 75, p. 1096,1104
反应条件
in water 5 h; Heating;
参考文献
Rabiger,D.J. et al.
Journal of Heterocyclic Chemistry, 1970 , vol. 7, p. 307 - 311
参考文献
Griess
Chemische Berichte, 1878 , vol. 11, p. 1734
Chemische Berichte, 1887 , vol. 20, p. 407
参考文献
Griess
Chemische Berichte, 1878 , vol. 11, p. 1734
Chemische Berichte, 1887 , vol. 20, p. 407
反应条件
hydrogenchloride; tin
参考文献
Griess
Chemische Berichte, 1878 , vol. 11, p. 1734
Chemische Berichte, 1887 , vol. 20, p. 407
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in acetonitrile T=25°C; Acylation; 14 h;
参考文献
Patel, Mona; McHugh Jr., Robert J.; Cordova, Beverly C.; Klabe, Ronald M.; Erickson-Viitanen, Susan; Trainor, George L.; Ko, Soo S.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 22 p. 3221 - 3224
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2006/71017 A1, 2006 ;
Location in patent: Page/Page column 34 ;
WO 2006/071017 A1
反应条件
T=210°C; Cycloaddition; 0.25 h;
参考文献
Chao, Qi; Deng, Lynn; Shih, Hsiencheng; Leoni, Lorenzo M.; Genini, Davide; Carson, Dennis A.; Cottam, Howard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3860 - 3873
